Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial.

Vicente Navarro-López ; Asunción Martínez-Andrés ; Ana Ramírez-Boscá ; Beatriz Ruzafa-Costas ; Eva Núñez-Delegido ; Miguel A Carrión-Gutiérrez ; David Prieto-Merino ORCID logo ; Francisco Codoñer-Cortés ; Daniel Ramón-Vidal ; Salvador Genovés-Martínez ; +4 more... Empar Chenoll-Cuadros ; José M Pérez-Orquín ; José A Picó-Monllor ; Sara Chumillas-Lidón ; (2019) Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial. Acta dermato-venereologica, 99 (12). pp. 1078-1084. ISSN 0001-5555 DOI: 10.2340/00015555-3305
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The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.


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