Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial.
Navarro-López, Vicente;
Martínez-Andrés, Asunción;
Ramírez-Boscá, Ana;
Ruzafa-Costas, Beatriz;
Núñez-Delegido, Eva;
Carrión-Gutiérrez, Miguel A;
Prieto-Merino, David;
Codoñer-Cortés, Francisco;
Ramón-Vidal, Daniel;
Genovés-Martínez, Salvador;
+4 more...Chenoll-Cuadros, Empar;
Pérez-Orquín, José M;
Picó-Monllor, José A;
Chumillas-Lidón, Sara;
(2019)
Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial.
Acta dermato-venereologica, 99 (12).
pp. 1078-1084.
ISSN 0001-5555
DOI: https://doi.org/10.2340/00015555-3305
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
