Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study.

Ina Danquah ; Juliet Addo ; Daniel Boateng ; Kerstin Klipstein-Grobusch ; Karlijn Meeks ORCID logo ; Cecilia Galbete ; Erik Beune ; Silver Bahendeka ; Joachim Spranger ; Frank P Mockenhaupt ; +4 more... Karien Stronks ; Charles Agyemang ORCID logo ; Matthias B Schulze ; Liam Smeeth ORCID logo ; (2019) Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study. Scientific reports, 9 (1). 10848-. ISSN 2045-2322 DOI: 10.1038/s41598-019-47169-6
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Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist circumference and type 2 diabetes among Ghanaian adults. In the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study, we calculated associations (adjusted for demographics and lifestyle) of parental education and anthropometric markers of childhood nutrition [leg length, leg length-to-height ratio (LHR)] with waist circumference and type 2 diabetes, respectively. Among 5,575 participants (mean age: 46.2 years; 62% female), lower education of either parent (vs. higher) was consistently associated with higher waist circumference (∆: 1.6-3.4 cm). Lower father's education tended to increase the odds of type 2 diabetes by 50% in women (95% confidence interval (CI): 1.0, 2.4). Reduced leg length and LHR were associated with higher waist circumference. But only in men, leg length was inversely related to type 2 diabetes (OR per 1 standard deviation decrease: 1.1; 95% CI: 1.0, 1.3). In this study, markers of poor childhood SES and early-life nutritional status relate to abdominal obesity in men and women and to type 2 diabetes in men. Thus, prevention efforts should start in early childhood.


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