Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.

Ashton, PORCID logo; Thanh, L; Trieu, P; Van Anh, D; Trinh, N; Beardsley, J; Kibengo, FORCID logo; Chierakul, WORCID logo; Dance, DORCID logo; Rattanavong, S; +14 more...Davong, V; Hung, L; Chau, N; Tung, N; Chan, A; Thwaites, G; Lalloo, DORCID logo; Anscombe, C; Nhat, L; Perfect, J; Dougan, G; Baker, S; Harris, S; Day, JORCID logo and (2019) Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans. Nature communications, 10 (1). 2035-. ISSN 2041-1723 DOI: 10.1038/s41467-019-10092-5
Copy

Cryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.


picture_as_pdf
Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.pdf
subject
Published Version
Available under Creative Commons: Attribution 3.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads