Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
; Holmans, P; Shi, J; Albus, M; Alexander, M; Campion, D; Cohen, D; Dikeos, D; Duan, J; Eichhammer, P; Godard, S; Hansen, M; Lerer, FB; Liang, K; Maier, W; Mallet, J; Nertney, DA; Nestadt, G; Norton, N; O'Neill, FA; Papadimitriou, GN; Ribble, R; Sanders, AR; Silverman, JM; Walsh, D; Williams, NM; Wormley, B; Psychosis Endophenotypes International Consortium; Arranz, MJ; Bakker, S; Bender, S; Bramon, E; Collier, D; Crespo-Facorro, B; Hall, J; Iyegbe, C; Jablensky, A; Kahn, RS; Kalaydjieva, L; Lawrie, S; Lewis, CM; Lin, K; Linszen, DH; Mata, I; McIntosh, A; Murray, RM; Ophoff, RA; Powell, J; Rujescu, D; Van Os, J; Walshe, M; Weisbrod, M; Wiersma, D; Wellcome Trust Case Control Consortium 2; Donnelly, P; Barroso, I; Blackwell, JM; Bramon, E; Brown, MA; Casas, JP; Corvin, AP; Deloukas, P; Duncanson, A; Jankowski, J; Markus, HS; Mathew, CG; Palmer, CN; Plomin, R; Rautanen, A; Sawcer, SJ; Trembath, RC; Viswanathan, AC; Wood, NW; Spencer, CC; Band, G; Bellenguez, C; Freeman, C; Hellenthal, G; Giannoulatou, E; Pirinen, M; Pearson, RD; Strange, A; Su, Z; Vukcevic, D; Donnelly, P; Langford, C; Hunt, SE; Edkins, S; Gwilliam, R; Blackburn, H; Bumpstead, SJ; Dronov, S; Gillman, M; Gray, E; Hammond, N; Jayakumar, A; McCann, OT; Liddle, J; Potter, SC; Ravindrarajah, R; Ricketts, M; Tashakkori-Ghanbaria, A; Waller, MJ; Weston, P; Widaa, S; Whittaker, P; Barroso, I; Deloukas, P; Mathew, CG; Blackwell, JM; Brown, MA; Corvin, AP; McCarthy, MI; Spencer, CC; Bramon, E; Corvin, AP; O'Donovan, MC; Stefansson, K; Scolnick, E; Purcell, S; McCarroll, SA; Sklar, P; Hultman, CM; Sullivan, PF and
(2013)
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
Nature genetics, 45 (10).
pp. 1150-1159.
ISSN 1061-4036
DOI: 10.1038/ng.2742
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
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