Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
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Peter
Holmans
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Jianxin
Shi
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Margot
Albus
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Madeline
Alexander
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Dominique
Campion
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David
Cohen
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Dimitris
Dikeos
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Jubao
Duan
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Peter
Eichhammer
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Stephanie
Godard
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Mark
Hansen
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F Bernard
Lerer
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Kung-Yee
Liang
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Wolfgang
Maier
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Jacques
Mallet
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Deborah A
Nertney
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Gerald
Nestadt
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Nadine
Norton
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Francis A
O'Neill
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George N
Papadimitriou
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Robert
Ribble
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Alan R
Sanders
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Jeremy M
Silverman
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Dermot
Walsh
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Nigel M
Williams
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Brandon
Wormley
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Psychosis Endophenotypes International Consortium
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Maria J
Arranz
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Steven
Bakker
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Stephan
Bender
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Elvira
Bramon
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David
Collier
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Benedicto
Crespo-Facorro
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Jeremy
Hall
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Conrad
Iyegbe
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Assen
Jablensky
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Rene S
Kahn
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Luba
Kalaydjieva
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Stephen
Lawrie
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Cathryn M
Lewis
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Kuang
Lin
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Don H
Linszen
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Ignacio
Mata
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Andrew
McIntosh
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Robin M
Murray
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Roel A
Ophoff
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John
Powell
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Dan
Rujescu
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Jim
Van Os
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Muriel
Walshe
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Matthias
Weisbrod
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Durk
Wiersma
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Wellcome Trust Case Control Consortium 2
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Peter
Donnelly
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Ines
Barroso
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Jenefer M
Blackwell
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Elvira
Bramon
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Matthew A
Brown
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Juan P
Casas
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Aiden P
Corvin
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Panos
Deloukas
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Audrey
Duncanson
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Janusz
Jankowski
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Hugh S
Markus
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Christopher G
Mathew
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Colin NA
Palmer
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Robert
Plomin
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Anna
Rautanen
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Stephen J
Sawcer
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Richard C
Trembath
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Ananth C
Viswanathan
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Nicholas W
Wood
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Chris CA
Spencer
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Gavin
Band
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Céline
Bellenguez
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Colin
Freeman
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Garrett
Hellenthal
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Eleni
Giannoulatou
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Matti
Pirinen
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Richard D
Pearson
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Amy
Strange
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Zhan
Su
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Damjan
Vukcevic
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Peter
Donnelly
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Cordelia
Langford
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Sarah E
Hunt
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Sarah
Edkins
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Rhian
Gwilliam
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Hannah
Blackburn
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Suzannah J
Bumpstead
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Serge
Dronov
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Matthew
Gillman
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Emma
Gray
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Naomi
Hammond
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Alagurevathi
Jayakumar
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Owen T
McCann
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Jennifer
Liddle
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Simon C
Potter
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Radhi
Ravindrarajah
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Michelle
Ricketts
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Avazeh
Tashakkori-Ghanbaria
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Matthew J
Waller
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Paul
Weston
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Sara
Widaa
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Pamela
Whittaker
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Ines
Barroso
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Panos
Deloukas
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Christopher G
Mathew
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Jenefer M
Blackwell
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Matthew A
Brown
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Aiden P
Corvin
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Mark I
McCarthy
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Chris CA
Spencer
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Elvira
Bramon
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Aiden P
Corvin
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Michael C
O'Donovan
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Kari
Stefansson
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Edward
Scolnick
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Shaun
Purcell
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Steven A
McCarroll
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Pamela
Sklar
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Christina M
Hultman
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Patrick F
Sullivan
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(2013)
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
Nature genetics, 45 (10).
pp. 1150-1159.
ISSN 1061-4036
DOI: 10.1038/ng.2742
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
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