Clonal variation within a mucosal isolate derived from a patient with Leishmania (Viannia) braziliensis infection
Cuba-Cuba, César Augusto;
Evans, David;
Rosa, Ana de Cassia;
Marsden, Philip Davis;
(1991)
Clonal variation within a mucosal isolate derived from a patient with Leishmania (Viannia) braziliensis infection.
Revista do Instituto de Medicina Tropical de Sao Paulo, 33 (5).
pp. 343-350.
ISSN 0036-4665
DOI: https://doi.org/10.1590/S0036-46651991000500002
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Three isolates over 5 years from a patient with persistent relapsing mucosal leishmaniasis due to Leishmania (Viannia) braziliensis and 7 clones from one of these isolates were studied by zymodemes and scrodemes analysis.
Results showed evidences of clonal phenotypic variation. Eight isoenzymes markers demonstrated clear differences on Cellulose Acetate (CA) and thin starch gel electrophoresis. Also a panel of specific monoclonal antibodies showed such differences.
Our observations provide additional evidence that Leishmania (Viannia) braziliensis is composed by subpopulations of parasites with peculiar biochemical and antigenic characteristics.
Key words: Leishmania (Viannia) braziliensis; Clonal Variation; Zymodemes; Serodemes.
