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Thomas J. Hladish, Carl A. B. Pearson, Diana Patricia Rojas, Hector Gomez-Dantes, M. Elizabeth Halloran, Gonzalo M. Vazquez-Prokopec, Ira M. Longini
Forecasting the effectiveness of indoor residual spraying for reducing dengue burden
www.plosntds.org
www.plosntds.org
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[()11()14(\r)4()11( )11()4()-4(\n)7()-4()]TJ
/F6 1 Tf
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
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(subsequent)Tj
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(regional)Tj
3.4809 0 Td
(expansion)Tj
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(and)Tj
-34.9452 -1.2982 Td
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(of)Tj
1.0148 0 Td
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3.3619 0 Td
(chikungunya,)Tj
5.6692 0 Td
(and)Tj
1.7291 0 Td
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-32.927 -1.2983 Td
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/F11 1 Tf
[()2()]TJ
/F6 1 Tf
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(larvicides\))Tj
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0.83 0.64 0.02 0 k
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0.83 0.64 0.02 0 k
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0.83 0.64 0.02 0 k
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-34.2649 -1.2983 Td
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([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(21)Tj
0 g
(].)Tj
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-34.2366 -1.3039 Td
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1.4456 0 Td
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2.3584 0 Td
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(and)Tj
1.7291 0 Td
(what)Tj
2.1657 0 Td
(options)Tj
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1.9219 0 Td
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3.5093 0 Td
(control)Tj
3.1238 0 Td
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-33.4656 -1.2982 Td
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3.0217 0 Td
(residual)Tj
3.3788 0 Td
(spraying)Tj
3.6397 0 Td
(\(IRS\))Tj
2.3414 0 Td
(is)Tj
0.8447 0 Td
(an)Tj
1.2019 0 Td
(example)Tj
3.549 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(well-understood)Tj
6.7691 0 Td
(approach)Tj
3.9515 0 Td
(with)Tj
1.9955 0 Td
(poten-)Tj
-33.5619 -1.2983 Td
(tially)Tj
2.1656 0 Td
(under-exploited)Tj
6.6444 0 Td
(promise)Tj
3.4866 0 Td
(for)Tj
/F11 1 Tf
1.3889 0 Td
[()30()2()]TJ
1.491 0 Td
[()6()9()-21()-13( )12(\n)7()]TJ
/F6 1 Tf
2.9821 0 Td
(control.)Tj
3.3505 0 Td
(IRS)Tj
1.6554 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(treatment)Tj
4.1329 0 Td
(of)Tj
1.0148 0 Td
(common)Tj
3.8494 0 Td
(mos-)Tj
-34.4803 -1.3039 Td
(quito)Tj
2.3243 0 Td
(resting)Tj
2.9537 0 Td
(surfaces)Tj
3.4129 0 Td
(inside)Tj
2.6135 0 Td
(houses)Tj
2.931 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(long-lasting)Tj
4.9606 0 Td
(insecticide.)Tj
4.6771 0 Td
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/F11 1 Tf
3.3902 0 Td
[()30()2()]TJ
1.491 0 Td
[()6()9()-21()-13( )12(\n)7()]TJ
/F6 1 Tf
-31.4019 -1.2983 Td
(strongly)Tj
3.4695 0 Td
(prefer)Tj
2.6192 0 Td
(feeding)Tj
3.1635 0 Td
(on)Tj
1.2755 0 Td
(humans)Tj
3.4356 0 Td
(and)Tj
1.7291 0 Td
(rest)Tj
1.6781 0 Td
(primarily)Tj
3.9685 0 Td
(indoors,)Tj
3.532 0 Td
(they)Tj
1.9275 0 Td
(are)Tj
1.4457 0 Td
(more)Tj
2.3414 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-33.9644 -1.2983 Td
(reached)Tj
3.3505 0 Td
(by)Tj
1.1792 0 Td
(IRS)Tj
1.6611 0 Td
(than)Tj
2.0239 0 Td
(by)Tj
1.1849 0 Td
(space)Tj
2.3811 0 Td
(sprays,)Tj
2.9423 0 Td
(especially)Tj
4.0195 0 Td
(outdoor)Tj
3.4639 0 Td
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4.1329 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0806 0 Td
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1.9446 0 Td
(other)Tj
2.347 0 Td
(insecticide-)Tj
-32.7115 -1.2982 Td
(based)Tj
2.4717 0 Td
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4.9606 0 Td
(IRS)Tj
1.6611 0 Td
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(specialized)Tj
4.524 0 Td
(training,)Tj
3.6454 0 Td
(is)Tj
0.8447 0 Td
(time-consuming)Tj
6.8484 0 Td
(to)Tj
1.0262 0 Td
(deliver,)Tj
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-33.9815 -1.3039 Td
(require)Tj
3.101 0 Td
(a)Tj
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1.0205 0 Td
(garner)Tj
2.8232 0 Td
(public)Tj
2.6986 0 Td
(acceptance,)Tj
4.7849 0 Td
(and)Tj
1.7234 0 Td
(must)Tj
2.2167 0 Td
(be)Tj
1.1395 0 Td
(tailored)Tj
3.2882 0 Td
(to)Tj
1.0148 0 Td
(region-specific)Tj
6.1114 0 Td
(factors,)Tj
-34.6844 -1.2983 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
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4.4504 0 Td
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4.1329 0 Td
(of)Tj
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(local)Tj
2.0806 0 Td
(mosquitoes.)Tj
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2.812 0 Td
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(officials)Tj
3.2995 0 Td
(will)Tj
1.6668 0 Td
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2.3527 0 Td
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3.1125 0 Td
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1.2756 0 Td
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3.3109 0 Td
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(scalability,)Tj
4.3823 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-34.0948 -1.3039 Td
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4.2462 0 Td
(effectiveness)Tj
5.2044 0 Td
(of)Tj
1.0148 0 Td
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1.8878 0 Td
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2.4492 0 Td
(scale)Tj
2.1089 0 Td
(empirical)Tj
3.9912 0 Td
(studies)Tj
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1.0261 0 Td
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2.2507 0 Td
(questions)Tj
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-34.2309 -1.2982 Td
(costly)Tj
2.5114 0 Td
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2.4775 0 Td
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2.4888 0 Td
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1.5533 0 Td
(mathematical)Tj
5.6466 0 Td
(modelscalibrated)Tj
7.5571 0 Td
(by)Tj
1.1792 0 Td
(real)Tj
1.6951 0 Td
(epidemic)Tj
3.8892 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
-34.5144 -1.2983 Td
(parametrized)Tj
5.5218 0 Td
(based)Tj
2.4718 0 Td
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1.2756 0 Td
(small-scale)Tj
4.5637 0 Td
(empirical)Tj
3.9912 0 Td
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(on)Tj
1.2756 0 Td
(IRS)Tj
1.6554 0 Td
(entomological)Tj
5.913 0 Td
(efficacy)Tj
3.2202 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
/F6 1 Tf
(.,)Tj
1.8992 0 Td
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-34.7752 -1.3039 Td
(on)Tj
1.2755 0 Td
(mosquito)Tj
4.0139 0 Td
(mortality\))Tj
4.2576 0 Td
(and)Tj
1.7291 0 Td
(durabilitycan)Tj
6.0434 0 Td
(provide)Tj
3.2882 0 Td
(a)Tj
0.6576 0 Td
(reasonable)Tj
4.4731 0 Td
(basis)Tj
2.1486 0 Td
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1.389 0 Td
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-28.0798 -1.2983 Td
(IRS)Tj
1.661 0 Td
(appears)Tj
3.2769 0 Td
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1.0261 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
0.6577 0 Td
(large)Tj
2.16 0 Td
(impact)Tj
2.9763 0 Td
(on)Tj
/F11 1 Tf
1.2756 0 Td
[()30()2()]TJ
1.491 0 Td
[()6()9()-21()-13( )12(\n)7()]TJ
/F6 1 Tf
2.9877 0 Td
(mortality.)Tj
4.1386 0 Td
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1.6611 0 Td
(campaigns)Tj
4.49 0 Td
(to)Tj
1.0262 0 Td
(eradicate)Tj
-32.0823 -1.2983 Td
(malaria)Tj
3.2257 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(Mediterranean)Tj
6.1851 0 Td
(region)Tj
2.8006 0 Td
(appear)Tj
2.9197 0 Td
(to)Tj
1.0205 0 Td
(have)Tj
2.0636 0 Td
(led)Tj
1.4173 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(elimination)Tj
4.8472 0 Td
(of)Tj
/F11 1 Tf
1.0148 0 Td
[()30()2()]TJ
1.491 0 Td
[()6()9()-21()-13( )12(\n)7()]TJ
/F6 1 Tf
2.982 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(],)Tj
-34.9679 -1.3039 Td
(and)Tj
1.7291 0 Td
(IRS)Tj
1.6554 0 Td
(either)Tj
2.5341 0 Td
(alone)Tj
2.3811 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(],)Tj
2.075 0 Td
(or)Tj
1.0998 0 Td
(in)Tj
1.0318 0 Td
(combination)Tj
5.3461 0 Td
(with)Tj
2.0013 0 Td
(larval)Tj
2.4037 0 Td
(control)Tj
3.1238 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(],)Tj
2.0749 0 Td
(contributed)Tj
4.921 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(elimi-)Tj
-34.8715 -1.2982 Td
(nation)Tj
2.8232 0 Td
(of)Tj
/F11 1 Tf
1.0148 0 Td
[()30()2()]TJ
1.491 0 Td
[()6()9()-21()-13( )12(\n)7()]TJ
/F6 1 Tf
2.9821 0 Td
(from)Tj
2.211 0 Td
(Guyana)Tj
3.3335 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(Cayman)Tj
3.5773 0 Td
(islands,)Tj
3.1861 0 Td
(respectively.)Tj
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2.5569 0 Td
(in)Tj
1.0375 0 Td
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-32.5245 -1.2983 Td
(Peru,)Tj
2.3243 0 Td
(indicates)Tj
3.7701 0 Td
(that)Tj
1.7801 0 Td
(treating)Tj
3.3279 0 Td
(household)Tj
4.3767 0 Td
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3.4072 0 Td
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1.9956 0 Td
(IRS)Tj
1.661 0 Td
(reduces)Tj
3.2769 0 Td
(the)Tj
1.4683 0 Td
(likelihood)Tj
4.2349 0 Td
(of)Tj
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(observing)Tj
-32.6378 -1.2983 Td
(adult)Tj
2.2506 0 Td
(mosquitoes)Tj
4.8019 0 Td
(by)Tj
/F12 1 Tf
0 Tc
1.1792 0 Td
(>)Tj
/F6 1 Tf
-0.004 Tc
(70%)Tj
2.7042 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(12)Tj
1.1679 0 Td
(weeks)Tj
2.6078 0 Td
(post)Tj
1.9049 0 Td
(spraying)Tj
3.6397 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
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2.0749 0 Td
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1.7291 0 Td
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5.4595 0 Td
(research)Tj
3.5547 0 Td
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-35.3648 -1.3039 Td
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3.0897 0 Td
(Australia)Tj
3.8437 0 Td
(indicates)Tj
3.7701 0 Td
(IRS)Tj
1.6554 0 Td
(led)Tj
1.4173 0 Td
(to)Tj
1.0262 0 Td
(86-96%)Tj
3.2314 0 Td
(reduction)Tj
4.1159 0 Td
(in)Tj
1.0318 0 Td
(dengue)Tj
3.1408 0 Td
(cases)Tj
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(in)Tj
1.0318 0 Td
(sprayed)Tj
3.3109 0 Td
(premises,)Tj
-32.8873 -1.2983 Td
(compared)Tj
4.2405 0 Td
(to)Tj
1.0262 0 Td
(unsprayed)Tj
4.388 0 Td
(controls)Tj
3.4809 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
2.0749 0 Td
(All)Tj
1.4004 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2506 0 Td
(results)Tj
2.812 0 Td
(indicate)Tj
3.4072 0 Td
(high)Tj
2.0126 0 Td
(IRS)Tj
1.6554 0 Td
(efficacy.)Tj
3.4469 0 Td
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-33.2104 -1.2982 Td
(durability,)Tj
4.3426 0 Td
(current)Tj
3.1861 0 Td
(IRS)Tj
1.6611 0 Td
(insecticides)Tj
4.8075 0 Td
(last)Tj
1.5591 0 Td
(an)Tj
1.2019 0 Td
(estimated)Tj
4.0762 0 Td
(three)Tj
2.262 0 Td
(months,)Tj
3.5093 0 Td
(but)Tj
1.5533 0 Td
(new)Tj
1.8766 0 Td
(formulations)Tj
-30.0357 -1.3039 Td
(might)Tj
2.5965 0 Td
(last)Tj
1.559 0 Td
(as)Tj
1.0148 0 Td
(long)Tj
1.9899 0 Td
(as)Tj
1.0148 0 Td
(five)Tj
1.6498 0 Td
(to)Tj
1.0261 0 Td
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