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Aurélie Fougère, Andrew P. Jackson, Dafni Paraskevi Bechtsi, Joanna A. M. Braks, Takeshi Annoura, Jannik Fonager, Roberta Spaccapelo, Jai Ramesar, Séverine Chevalley-Maurel, Onny Klop, Annelies M. A. van der Laan, Hans J. Tanke, Clemens H. M. Kocken, Erica M. Pasini, Shahid M. Khan, Ulrike Böhme, Christiaan van Ooij, Thomas D. Otto, Chris J. Janse, Blandine Franke-Fayard
Correction: Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole
www.plospathogens.org
www.plospathogens.org
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234.2846 300.8903 m
186.4298 300.8903 l
186.4298 301.3903 l
233.7846 301.3903 l
f*
304.4364 332.3903 m
304.4364 300.8903 l
303.9364 301.3903 l
303.9364 332.3903 l
f*
304.4364 300.8903 m
234.2846 300.8903 l
234.2846 301.3903 l
303.9364 301.3903 l
f*
368.8143 332.3903 m
368.8143 300.8903 l
368.3143 301.3903 l
368.3143 332.3903 l
f*
368.8143 300.8903 m
304.4364 300.8903 l
304.4364 301.3903 l
368.3143 301.3903 l
f*
443.8536 332.3903 m
443.8536 300.8903 l
443.3536 301.3903 l
443.3536 332.3903 l
f*
443.8536 300.8903 m
368.8143 300.8903 l
368.8143 301.3903 l
443.3536 301.3903 l
f*
516.5433 332.3903 m
516.5433 300.8903 l
516.0433 301.3903 l
516.0433 332.3903 l
f*
516.5433 300.8903 m
443.8536 300.8903 l
443.8536 301.3903 l
516.0433 301.3903 l
f*
576 300.8903 m
516.5433 300.8903 l
516.5433 301.3903 l
576 301.3903 l
f*
576 288.3903 m
36 288.3903 l
36 288.8904 l
576 288.8904 l
f*
84.1235 288.3903 m
84.1235 266.3904 l
83.6235 266.8904 l
83.6235 288.3903 l
f*
84.1235 266.3904 m
36 266.3904 l
36 266.8904 l
83.6235 266.8904 l
f*
145.0919 288.3903 m
145.0919 266.3904 l
144.5919 266.8904 l
144.5919 288.3903 l
f*
145.0919 266.3904 m
84.1235 266.3904 l
84.1235 266.8904 l
144.5919 266.8904 l
f*
186.4298 288.3903 m
186.4298 266.3904 l
185.9298 266.8904 l
185.9298 288.3903 l
f*
186.4298 266.3904 m
145.0919 266.3904 l
145.0919 266.8904 l
185.9298 266.8904 l
f*
234.2846 288.3903 m
234.2846 266.3904 l
233.7846 266.8904 l
233.7846 288.3903 l
f*
234.2846 266.3904 m
186.4298 266.3904 l
186.4298 266.8904 l
233.7846 266.8904 l
f*
304.4364 288.3903 m
304.4364 266.3904 l
303.9364 266.8904 l
303.9364 288.3903 l
f*
304.4364 266.3904 m
234.2846 266.3904 l
234.2846 266.8904 l
303.9364 266.8904 l
f*
368.8143 288.3903 m
368.8143 266.3904 l
368.3143 266.8904 l
368.3143 288.3903 l
f*
368.8143 266.3904 m
304.4364 266.3904 l
304.4364 266.8904 l
368.3143 266.8904 l
f*
443.8536 288.3903 m
443.8536 266.3904 l
443.3536 266.8904 l
443.3536 288.3903 l
f*
443.8536 266.3904 m
368.8143 266.3904 l
368.8143 266.8904 l
443.3536 266.8904 l
f*
516.5433 288.3903 m
516.5433 266.3904 l
516.0433 266.8904 l
516.0433 288.3903 l
f*
516.5433 266.3904 m
443.8536 266.3904 l
443.8536 266.8904 l
516.0433 266.8904 l
f*
576 266.3904 m
516.5433 266.3904 l
516.5433 266.8904 l
576 266.8904 l
f*
84.1235 266.3904 m
84.1235 244.3904 l
83.6235 244.8904 l
83.6235 266.3904 l
f*
84.1235 244.3904 m
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83.6235 244.8904 l
f*
145.0919 266.3904 m
145.0919 244.3904 l
144.5919 244.8904 l
144.5919 266.3904 l
f*
145.0919 244.3904 m
84.1235 244.3904 l
84.1235 244.8904 l
144.5919 244.8904 l
f*
186.4298 266.3904 m
186.4298 244.3904 l
185.9298 244.8904 l
185.9298 266.3904 l
f*
186.4298 244.3904 m
145.0919 244.3904 l
145.0919 244.8904 l
185.9298 244.8904 l
f*
234.2846 266.3904 m
234.2846 244.3904 l
233.7846 244.8904 l
233.7846 266.3904 l
f*
234.2846 244.3904 m
186.4298 244.3904 l
186.4298 244.8904 l
233.7846 244.8904 l
f*
304.4364 266.3904 m
304.4364 244.3904 l
303.9364 244.8904 l
303.9364 266.3904 l
f*
304.4364 244.3904 m
234.2846 244.3904 l
234.2846 244.8904 l
303.9364 244.8904 l
f*
368.8143 266.3904 m
368.8143 244.3904 l
368.3143 244.8904 l
368.3143 266.3904 l
f*
368.8143 244.3904 m
304.4364 244.3904 l
304.4364 244.8904 l
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f*
443.8536 266.3904 m
443.8536 244.3904 l
443.3536 244.8904 l
443.3536 266.3904 l
f*
443.8536 244.3904 m
368.8143 244.3904 l
368.8143 244.8904 l
443.3536 244.8904 l
f*
516.5433 266.3904 m
516.5433 244.3904 l
516.0433 244.8904 l
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f*
516.5433 244.3904 m
443.8536 244.3904 l
443.8536 244.8904 l
516.0433 244.8904 l
f*
576 244.3904 m
516.5433 244.3904 l
516.5433 244.8904 l
576 244.8904 l
f*
576 222.6402 m
36 222.6402 l
36 223.1402 l
576 223.1402 l
f*
0.83 0.64 0.02 0 k
41.1591 227.5654 m
102.4441 227.5654 l
h
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F3 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.0417 0 Td
(Features)Tj
4.3229 0 Td
(of)Tj
1.1551 0 Td
(tagged)Tj
3.4654 0 Td
(member)Tj
3.8268 0 Td
(s)Tj
0.7654 0 Td
(of)Tj
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(the)Tj
/F11 1 Tf
1.7008 0 Td
(pir)Tj
/F3 1 Tf
(,)Tj
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1.7575 0 Td
(fam-a)Tj
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(and)Tj
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1.9843 0 Td
(fam-b)Tj
/F3 1 Tf
2.9055 0 Td
(multigene)Tj
4.8898 0 Td
(families)Tj
3.6639 0 Td
(.)Tj
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(Name)Tj
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(tagged)Tj
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(protein)Tj
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(Fluore)Tj
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(scent)Tj
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(tag)Tj
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(Mutant)Tj
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(name)Tj
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(RMgmDB)Tj
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ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 212.4283 687.9685 cm
BT
/F3 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 360.737 693.8645 cm
BT
/F3 1 Tf
1 TL
0 0 Td
(BLOOD)Tj
21.7206 0 Td
(LIVER)Tj
-36.801 -1.6228 Td
(expressi)Tj
4.0252 0 Td
(on)Tj
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(and)Tj
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(localisati)Tj
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(of)Tj
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(clones)Tj
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(uores)Tj
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(cent)Tj
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(uoresce)Tj
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(nt)Tj
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(before)Tj
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(passag)Tj
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(e)Tj
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(\(%\))Tj
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(uoresce)Tj
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(after)Tj
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(e)Tj
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(on)Tj
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(gene-tagg)Tj
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(ing)Tj
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(mutants)Tj
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(mCherry)Tj
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(1477cl)Tj
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(3)Tj
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(690)Tj
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(=)Tj
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(GFP)Tj
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(1283)Tj
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(Yes;)Tj
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(RBC)Tj
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(s)Tj
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(N.A.)Tj
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(30%)Tj
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(No)Tj
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(Fam-a2)Tj
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(mCherry)Tj
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(1448cl)Tj
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(2)Tj
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(693)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(=)Tj
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(5\))Tj
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(99%)Tj
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(85100)Tj
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(Yes;)Tj
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(Fam-b1)Tj
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(mCherry)Tj
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(1599cl)Tj
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(4)Tj
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(699)Tj
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(pa)Tj
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(66%)Tj
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(=)Tj
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(3\))Tj
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(Yes;)Tj
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(mCherry)Tj
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(1731cl)Tj
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(700)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(100%)Tj
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(=)Tj
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(5\))Tj
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(65%)Tj
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(5070%)Tj
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(Yes;)Tj
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(PV)Tj
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(Fam-b2)Tj
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(GFP)Tj
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(1942)Tj
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(1282)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(N.A.)Tj
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(5075%)Tj
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(N.D.)Tj
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(N.D)Tj
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(PIR1)Tj
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(mCherry)Tj
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(1531cl)Tj
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(3)Tj
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(695)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(100%)Tj
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(\(n)Tj
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(=)Tj
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(5\))Tj
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(15%)Tj
8.4047 0 Td
(6070%)Tj
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(Yes;)Tj
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(PV)Tj
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(PIR1)Tj
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(mCherry)Tj
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(1944cl)Tj
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(1)Tj
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(1281)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(66%)Tj
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(\(n)Tj
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(=)Tj
0.815 0 Td
(3\))Tj
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(1020%)Tj
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(N.D.)Tj
8.2914 0 Td
(N.D.)Tj
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(PIR2)Tj
7.0796 0 Td
(GFP)Tj
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(603cl3)Tj
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(696)Tj
5.0103 0 Td
(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(75%)Tj
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(\(n)Tj
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(=)Tj
0.815 0 Td
(4\))Tj
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(510%)Tj
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(5%)Tj
8.3693 0 Td
(No)Tj
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(PIR3)Tj
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(mCherry)Tj
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(1918cl)Tj
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(4)Tj
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(697)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(25%)Tj
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(=)Tj
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(4\))Tj
5.485 0 Td
(1%-5%)Tj
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(N.D.)Tj
8.6528 0 Td
(No)Tj
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(PIR4)Tj
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(mCherry)Tj
7.2 0 Td
(2450)Tj
5.5772 0 Td
(1233)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(N.A.)Tj
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(0.12%)Tj
9.9213 0 Td
(N.D.)Tj
8.6528 0 Td
(No)Tj
-61.4626 -1.5661 Td
(PIR5)Tj
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(mCherry)Tj
6.5693 0 Td
(2448cl)Tj
2.9126 0 Td
(1)Tj
3.2953 0 Td
(1234)Tj
5.2867 0 Td
(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(100%)Tj
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(\(n)Tj
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(=)Tj
0.815 0 Td
(3\))Tj
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(2550%)Tj
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(N.D.)Tj
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(N.D.)Tj
-61.1012 -1.5591 Td
(PIR6)Tj
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(mCherry)Tj
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(1892)Tj
5.8536 0 Td
(698)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(N.A.)Tj
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8.263 0 Td
[( )]TJ
/F0 1 Tf
(0.1%)Tj
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(N.D.)Tj
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(N.D.)Tj
-61.1012 -1.5662 Td
(PIR7)Tj
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(mCherry)Tj
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(2211)Tj
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(1235)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(N.A.)Tj
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[( )]TJ
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(N.D.)Tj
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(N.D.)Tj
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(PIR8)Tj
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(mCherry)Tj
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(2312,)Tj
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(2313)Tj
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(1236)Tj
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(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(N.A.)Tj
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(5060%)Tj
9.2339 0 Td
(3060%)Tj
7.3135 0 Td
(yes,)Tj
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(parasite)Tj
0.0992 -1.1906 Td
(cyt)Tj
/F3 1 Tf
-63.1492 -1.5591 Td
(Double)Tj
3.6142 0 Td
(gene-taggi)Tj
5.0457 0 Td
(ng)Tj
1.4599 0 Td
(mutant)Tj
3.3165 0 Td
(s)Tj
0.7867 0 Td
(\(multigen)Tj
4.4929 0 Td
(e)Tj
0.7795 0 Td
(families\))Tj
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-18.4182 -1.5661 Td
(Fam-a2)Tj
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(Fam-a1)Tj
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-0.6945 -1.1905 Td
(Fam-a2/a1)Tj
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7.5048 2.374 Td
(mCherry)Tj
0.8787 -1.1835 Td
(GFP)Tj
-2.2394 -1.1905 Td
(mCherry&GF)Tj
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(P)Tj
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(2010)Tj
-0.333 -1.1835 Td
(\(2011\))Tj
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(1244)Tj
5.2867 0 Td
(Yes;)Tj
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(RBC)Tj
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(c)Tj
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(pa)Tj
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(Yes;)Tj
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(RBC)Tj
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(s)Tj
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(N.A.)Tj
7.8661 0 Td
(7080%)Tj
0 -1.1835 Td
(4065%)Tj
0 -1.1905 Td
(4055%)Tj
9.2339 2.374 Td
(7080%)Tj
0 -1.1835 Td
(4550%)Tj
0 -1.1905 Td
(3040%)Tj
8.334 2.374 Td
(Yes;)Tj
2.2252 0 Td
(PV)Tj
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(\()Tj
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[( !)]TJ
/F0 1 Tf
(90%\))Tj
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(No)Tj
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(Fam-a2)Tj
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(Fam-a1)Tj
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-0.6945 -1.1834 Td
(Fam-a2/a1)Tj
/F0 1 Tf
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