Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.

Síle F Molloy ; John Bradley ORCID logo ; Natasha Karunaharan ; Muhammad Mputu ; Neil Stone ; Jacob Phulusa ; Chimwemwe Chawinga ; Kate Gaskell ORCID logo ; Dalitso Segula ; Damien Ming ; +7 more... Mary Peirse ; Duncan Chanda ; Shabir Lakhi ; Angela Loyse ; Cecilia Kanyama ; Robert S Heyderman ; Thomas S Harrison ; (2018) Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis. AIDS (London, England), 32 (15). pp. 2259-2261. ISSN 0269-9370 DOI: 10.1097/QAD.0000000000001961
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: We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR: -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
Item Type Article
Date Deposited 16 Aug 2018 10:35

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