Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort.

Jackson, Charlotte; Southern, Jo; Lalvani, Ajit; Drobniewski, Francis; Griffiths, Chris J; Lipman, Marc; Bothamley, Graham H; Deeks, Jonathan J; Imran, Ambreen; Kon, Onn Min; +8 more... Mpofu, Sithembinkosi; Nikolayevskyy, Vladyslav; Rees-Roberts, Melanie; Sitch, Alice; Sridhar, Saranya; Tsou, Chuen-Yan; Whitworth, Hilary; Abubakar, Ibrahim; (2018) Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax, 74 (1). pp. 91-94. ISSN 0040-6376 DOI: https://doi.org/10.1136/thoraxjnl-2017-211124

Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). TRIAL REGISTRATION NUMBER: PREDICT is registered on clinicaltrials.gov (NCT01162265).

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID	29764958