Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort.

Charlotte Jackson ORCID logo ; Jo Southern ; Ajit Lalvani ; Francis Drobniewski ; Chris J Griffiths ; Marc Lipman ; Graham H Bothamley ; Jonathan J Deeks ; Ambreen Imran ; Onn Min Kon ; +8 more... Sithembinkosi Mpofu ; Vladyslav Nikolayevskyy ; Melanie Rees-Roberts ; Alice Sitch ; Saranya Sridhar ; Chuen-Yan Tsou ; Hilary Whitworth ORCID logo ; Ibrahim Abubakar ; (2018) Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax, 74 (1). pp. 91-94. ISSN 0040-6376 DOI: 10.1136/thoraxjnl-2017-211124
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We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). TRIAL REGISTRATION NUMBER: PREDICT is registered on clinicaltrials.gov (NCT01162265).


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