Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort.
Charlotte
Jackson
;
Jo
Southern
;
Ajit
Lalvani
;
Francis
Drobniewski
;
Chris J
Griffiths
;
Marc
Lipman
;
Graham H
Bothamley
;
Jonathan J
Deeks
;
Ambreen
Imran
;
Onn Min
Kon
;
+8 more...
Sithembinkosi
Mpofu
;
Vladyslav
Nikolayevskyy
;
Melanie
Rees-Roberts
;
Alice
Sitch
;
Saranya
Sridhar
;
Chuen-Yan
Tsou
;
Hilary
Whitworth
;
Ibrahim
Abubakar
;
(2018)
Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort.
Thorax, 74 (1).
pp. 91-94.
ISSN 0040-6376
DOI: 10.1136/thoraxjnl-2017-211124
We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). TRIAL REGISTRATION NUMBER: PREDICT is registered on clinicaltrials.gov (NCT01162265).
Item Type | Article |
---|---|
Date Deposited | 22 May 2018 01:18 |
ORCID: https://orcid.org/0000-0001-8544-7685
ORCID: https://orcid.org/0000-0003-2353-2352