Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Jayaram
Vijayakrishnan
;
James
Studd
;
Peter
Broderick
;
Ben
Kinnersley
;
Amy
Holroyd
;
Philip J
Law
;
Rajiv
Kumar
;
James M
Allan
;
Christine J
Harrison
;
Anthony V
Moorman
;
+30 more...
Ajay
Vora
;
Eve
Roman
;
Sivaramakrishna
Rachakonda
;
Sally E
Kinsey
;
Eamonn
Sheridan
;
Pamela D
Thompson
;
Julie A
Irving
;
Rolf
Koehler
;
Per
Hoffmann
;
Markus M
Nöthen
;
Stefanie
Heilmann-Heimbach
;
Karl-Heinz
Jöckel
;
Douglas F
Easton
;
Paul DP
Pharaoh
;
Alison M
Dunning
;
Julian
Peto
;
Frederico
Canzian
;
Anthony
Swerdlow
;
Rosalind A
Eeles
;
ZSofia
Kote-Jarai
;
Kenneth
Muir
;
Nora
Pashayan
;
PRACTICAL Consortium
;
Mel
Greaves
;
Martin
Zimmerman
;
Claus R
Bartram
;
Martin
Schrappe
;
Martin
Stanulla
;
Kari
Hemminki
;
Richard S
Houlston
;
(2018)
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature communications, 9 (1).
1340-.
ISSN 2041-1723
DOI: 10.1038/s41467-018-03178-z
;
Peter
Broderick
;
Ben
Kinnersley
;
Amy
Holroyd
;
Philip J
Law
;
Rajiv
Kumar
;
James M
Allan
;
Christine J
Harrison
;
Anthony V
Moorman
;
+30 more...
Ajay
Vora
;
Eve
Roman
;
Sivaramakrishna
Rachakonda
;
Sally E
Kinsey
;
Eamonn
Sheridan
;
Pamela D
Thompson
;
Julie A
Irving
;
Rolf
Koehler
;
Per
Hoffmann
;
Markus M
Nöthen
;
Stefanie
Heilmann-Heimbach
;
Karl-Heinz
Jöckel
;
Douglas F
Easton
;
Paul DP
Pharaoh
;
Alison M
Dunning
;
Julian
Peto
;
Frederico
Canzian
;
Anthony
Swerdlow
;
Rosalind A
Eeles
;
ZSofia
Kote-Jarai
;
Kenneth
Muir
;
Nora
Pashayan
;
PRACTICAL Consortium
;
Mel
Greaves
;
Martin
Zimmerman
;
Claus R
Bartram
;
Martin
Schrappe
;
Martin
Stanulla
;
Kari
Hemminki
;
Richard S
Houlston
;
(2018)
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature communications, 9 (1).
1340-.
ISSN 2041-1723
DOI: 10.1038/s41467-018-03178-z
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
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