Sud, Amit; Thomsen, Hauke; Law, Philip J; Försti, Asta; Filho, Miguel Inacio da Silva; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg; Wright, Lauren; +26 more... Cooke, Rosie; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Eeles, Rosalind; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora; PRACTICAL consortium; Hoffmann, Per; Nöthen, Markus M; Jöckel, Karl-Heinz; Strandmann, Elke Pogge von; Lightfoot, Tracy; Kane, Eleanor; Roman, Eve; Lake, Annette; Montgomery, Dorothy; Jarrett, Ruth F; Swerdlow, Anthony J; Engert, Andreas; Orr, Nick; Hemminki, Kari; Houlston, Richard S; (2017) Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nature communications, 8 (1). 1892-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-017-00320-1
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Abstract
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
Item Type | Article |
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Faculty and Department |
Faculty of Infectious and Tropical Diseases > Dept of Disease Control Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
PubMed ID | 29196614 |
ISI | 416933400014 |
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