Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Yoshio
Nakatani
;
Helen K
Opel-Reading
;
Matthias
Merker
;
Diana
Machado
;
Sönke
Andres
;
S Siva
Kumar
;
Danesh
Moradigaravand
;
Francesc
Coll
;
João
Perdigão
;
Isabel
Portugal
;
+19 more...
Thomas
Schön
;
Dina
Nair
;
KR Uma
Devi
;
Thomas A
Kohl
;
Patrick
Beckert
;
Taane G
Clark
;
Gugu
Maphalala
;
Derrick
Khumalo
;
Roland
Diel
;
Kadri
Klaos
;
Htin Lin
Aung
;
Gregory M
Cook
;
Julian
Parkhill
;
Sharon J
Peacock
;
Soumya
Swaminathan
;
Miguel
Viveiros
;
Stefan
Niemann
;
Kurt L
Krause
;
Claudio U
Köser
;
(2017)
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrobial agents and chemotherapy, 61 (12).
ISSN 0066-4804
DOI: 10.1128/AAC.01575-17
;
João
Perdigão
;
Isabel
Portugal
;
+19 more...
Thomas
Schön
;
Dina
Nair
;
KR Uma
Devi
;
Thomas A
Kohl
;
Patrick
Beckert
;
Taane G
Clark
;
Gugu
Maphalala
;
Derrick
Khumalo
;
Roland
Diel
;
Kadri
Klaos
;
Htin Lin
Aung
;
Gregory M
Cook
;
Julian
Parkhill
;
Sharon J
Peacock
;
Soumya
Swaminathan
;
Miguel
Viveiros
;
Stefan
Niemann
;
Kurt L
Krause
;
Claudio U
Köser
;
(2017)
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrobial agents and chemotherapy, 61 (12).
ISSN 0066-4804
DOI: 10.1128/AAC.01575-17
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
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picture_as_pdf - Role of alanine racemase mutations_GREEN AAM.pdf
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subject - Accepted Version
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- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0
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