Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies.
Farrington, CP;
Firth, MJ;
Moulton, LH;
Ravn, H;
Andersen, PK;
Evans, S;
Working Group on Non-specific Effects of Vaccines;
(2009)
Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies.
Tropical medicine & international health, 14 (9).
pp. 977-985.
ISSN 1360-2276
DOI: https://doi.org/10.1111/j.1365-3156.2009.02302.x
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We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.
