Etyang, AO; Wandabwa, CK; Kapesa, S; Muthumbi, E; Odipo, E; Wamukoya, M; Ngomi, N; Haregu, T; Kyobutungi, C; Williams, TN; +5 more... Makale, J; Macharia, A; Cruickshank, JK; Smeeth, L; Scott, JAG; (2017) Blood Pressure and Arterial Stiffness in Kenyan Adolescents with the Sickle Cell Trait. American journal of epidemiology. ISSN 0002-9262 DOI: https://doi.org/10.1093/aje/kwx232
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
The potential association between sickle cell trait (SCT) and increased arterial stiffness/blood pressure (BP) has not been evaluated in detail despite its association with stroke, sudden death and renal disease. We performed 24-hour ambulatory BP monitoring and arterial stiffness measurements in adolescents raised in a malaria free environment in Kenya.Between December 2015 and June 2016, 938 randomly selected adolescents that had been continuous residents of Nairobi from birth were invited to participate in the study. Standard clinic BP measurement was performed followed by 24-hour ambulatory BP monitoring and arterial stiffness measurement using an Arteriograph device. SCT status was determined using DNA genotyping on contemporaneously collected blood samples. Of 938 invited, 609 (65%) provided complete data for analysis. SCT was present in 103 (17%). Mean 24-hour systolic and diastolic BP, SD was (116, 11.5) and (64, 7) mmHg respectively in SCT; and (117, 11.4) and (64, 6.8) in non-SCT. Mean pulse wave velocity (PWV), SD was (7, 0.8) and (7, 0.8) ms-1 respectively in SCT and non-SCT. No differences were observed in PWV and any clinic or ambulatory BP derived measures between those with and without SCT. These data suggest that SCT does not independently influence BP or PWV.
Item Type | Article |
---|---|
Faculty and Department |
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
Research Centre | EHR Research Group |
PubMed ID | 28992220 |
ISI | 423821100003 |
Related URLs |
Download
Filename: Blood Pressure and Arterial Stiffness_GREEN AAM.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
Download