Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited.
Keays, David A;
Clark, Taane G;
Campbell, Thomas G;
Broxholme, John;
Valdar, William;
(2007)
Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited.
Mammalian genome, 18 (2).
pp. 123-124.
ISSN 0938-8990
DOI: https://doi.org/10.1007/s00335-006-0065-z
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We recently described methods for estimating the number of N-ethyl-N-nitrosourea (ENU)-induced coding mutations in phenotypic and genotypic screens. In this article we revisit these methods, clarifying their application. In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ( http://www.well.ox.ac.uk/enuMutRat ).
