Dendooven, Amélie;
Ishola, David A;
Nguyen, Tri Q;
Van der Giezen, Dionne M;
Kok, Robbert Jan;
Goldschmeding, Roel;
Joles, Jaap A;
(2010)
Oxidative stress in obstructive nephropathy.
International journal of experimental pathology, 92 (3).
pp. 202-210.
ISSN 0959-9673
DOI: https://doi.org/10.1111/j.1365-2613.2010.00730.x
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Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.
