Common variants at five new loci associated with early-onset inflammatory bowel disease.

Imielinski, M; Baldassano, RN; Griffiths, A; Russell, RK; Annese, V; Dubinsky, M; Kugathasan, S; Bradfield, JP; Walters, TD; Sleiman, P; +108 more...Kim, CE; Muise, A; Wang, K; Glessner, JT; Saeed, S; Zhang, H; Frackelton, EC; Hou, C; Flory, JH; Otieno, G; Chiavacci, RM; Grundmeier, R; Castro, M; Latiano, A; Dallapiccola, B; Stempak, J; Abrams, DJ; Taylor, K; McGovern, D; Western Regional Alliance for Pediatric IBD; Silber, G; Wrobel, I; Quiros, A; International IBD Genetics Consortium; Barrett, JC; Hansoul, S; Nicolae, DL; Cho, JH; Duerr, RH; Rioux, JD; Brant, SR; Silverberg, MS; Taylor, KD; Barmuda, MM; Bitton, A; Dassopoulos, T; Datta, LW; Green, T; Griffiths, AM; Kistner, EO; Murtha, MT; Regueiro, MD; Rotter, JI; Schumm, LP; Steinhart, AH; Targan, SR; Xavier, RJ; NIDDK IBD Genetics Consortium; Libioulle, C; Sandor, C; Lathrop, M; Belaiche, J; Dewit, O; Gut, I; Heath, S; Laukens, D; Mni, M; Rutgeerts, P; Van Gossum, A; Zelenika, D; Franchimont, D; Hugot, J; de Vos, M; Vermeire, S; Louis, E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium; Cardon, LR; Anderson, CA; Drummond, H; Nimmo, E; Ahmad, T; Prescott, NJ; Onnie, CM; Fisher, SA; Marchini, J; Ghori, J; Bumpstead, S; Gwillam, R; Tremelling, M; Delukas, P; Mansfield, J; Jewell, D; Satsangi, J; Mathew, CG; Parkes, M; Georges, M; Daly, MJ; Heyman, MB; Ferry, GD; Kirschner, B; Lee, J; Essers, J; Grand, R; Stephens, M; Levine, A; Piccoli, D; Van Limbergen, J; Cucchiara, S; Monos, DS; Guthery, SL; Denson, L; Wilson, DC; Grant, SF; Daly, M; Silverberg, MS; Satsangi, J; Hakonarson, H and (2009) Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet, 41 (12). pp. 1335-1340. ISSN 1061-4036 DOI: 10.1038/ng.489
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The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
Item Type Article
Date Deposited 17 Oct 2011 14:49

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