Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Jeffrey C
Barrett
;
Sarah
Hansoul
;
Dan L
Nicolae
;
Judy H
Cho
;
Richard H
Duerr
;
John D
Rioux
;
Steven R
Brant
;
Mark S
Silverberg
;
Kent D
Taylor
;
M Michael
Barmada
;
+54 more...
Alain
Bitton
;
Themistocles
Dassopoulos
;
Lisa Wu
Datta
;
Todd
Green
;
Anne M
Griffiths
;
Emily O
Kistner
;
Michael T
Murtha
;
Miguel D
Regueiro
;
Jerome I
Rotter
;
L Philip
Schumm
;
A Hillary
Steinhart
;
Stephan R
Targan
;
Ramnik J
Xavier
;
NIDDK IBD Genetics Consortium
;
Cécile
Libioulle
;
Cynthia
Sandor
;
Mark
Lathrop
;
Jacques
Belaiche
;
Olivier
Dewit
;
Ivo
Gut
;
Simon
Heath
;
Debby
Laukens
;
Myriam
Mni
;
Paul
Rutgeerts
;
André
Van Gossum
;
Diana
Zelenika
;
Denis
Franchimont
;
Jean-Pierre
Hugot
;
Martine
de Vos
;
Severine
Vermeire
;
Edouard
Louis
;
Belgian-French IBD Consortium
;
Wellcome Trust Case Control Consortium
;
Lon R
Cardon
;
Carl A
Anderson
;
Hazel
Drummond
;
Elaine
Nimmo
;
Tariq
Ahmad
;
Natalie J
Prescott
;
Clive M
Onnie
;
Sheila A
Fisher
;
Jonathan
Marchini
;
Jilur
Ghori
;
Suzannah
Bumpstead
;
Rhian
Gwilliam
;
Mark
Tremelling
;
Panos
Deloukas
;
John
Mansfield
;
Derek
Jewell
;
Jack
Satsangi
;
Christopher G
Mathew
;
Miles
Parkes
;
Michel
Georges
;
Mark J
Daly
;
(2008)
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Nat Genet, 40 (8).
pp. 955-962.
ISSN 1061-4036
DOI: 10.1038/ng.175
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
| Item Type | Article |
|---|---|
| Date Deposited | 17 Oct 2011 14:49 |