Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Sheila A
Fisher
;
Mark
Tremelling
;
Carl A
Anderson
;
Rhian
Gwilliam
;
Suzannah
Bumpstead
;
Natalie J
Prescott
;
Elaine R
Nimmo
;
Dunecan
Massey
;
Carlo
Berzuini
;
Christopher
Johnson
;
+27 more...
Jeffrey C
Barrett
;
Fraser R
Cummings
;
Hazel
Drummond
;
Charlie W
Lees
;
Clive M
Onnie
;
Catherine E
Hanson
;
Katarzyna
Blaszczyk
;
Mike
Inouye
;
Philip
Ewels
;
Radhi
Ravindrarajah
;
Andrew
Keniry
;
Sarah
Hunt
;
Martyn
Carter
;
Nick
Watkins
;
Willem
Ouwehand
;
Cathryn M
Lewis
;
Lon
Cardon
;
Wellcome Trust Case Control Consortium
;
Alan
Lobo
;
Alastair
Forbes
;
Jeremy
Sanderson
;
Derek P
Jewell
;
John C
Mansfield
;
Panos
Deloukas
;
Christopher G
Mathew
;
Miles
Parkes
;
Jack
Satsangi
;
(2008)
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Nat Genet, 40 (6).
pp. 710-712.
ISSN 1061-4036
DOI: 10.1038/ng.145
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
| Item Type | Article |
|---|---|
| Date Deposited | 17 Oct 2011 14:49 |