Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
; Colli, LM; Li, P; Sampson, JN; Abedi-Ardekani, B; Besse, C; Blanche, H; Boland, A; Burdette, L; Chabrier, A; Durand, G; Le Calvez-Kelm, F; Prokhortchouk, E; Robinot, N; Skryabin, KG; Wozniak, MB; Yeager, M; Basta-Jovanovic, G; Dzamic, Z; Foretova, L; Holcatova, I; Janout, V; Mates, D; Mukeriya, A; Rascu, S; Zaridze, D; Bencko, V; Cybulski, C; Fabianova, E; Jinga, V; Lissowska, J; Lubinski, J; Navratilova, M; Rudnai, P; Szeszenia-Dabrowska, N; Benhamou, S; Cancel-Tassin, G; Cussenot, O; Baglietto, L; Boeing, H; Khaw, K; Weiderpass, E; Ljungberg, B; Sitaram, RT; Bruinsma, F; Jordan, SJ; Severi, G; Winship, I; Hveem, K; Vatten, LJ; Fletcher, T; Koppova, K; Larsson, SC; Wolk, A; Banks, RE; Selby, PJ; Easton, DF; Pharoah, P; Andreotti, G; Freeman, LEB; Koutros, S; Albanes, D; Männistö, S; Weinstein, S; Clark, PE; Edwards, TL; Lipworth, L; Gapstur, SM; Stevens, VL; Carol, H; Freedman, ML; Pomerantz, MM; Cho, E; Kraft, P; Preston, MA; Wilson, KM; Michael Gaziano, J; Sesso, HD; Black, A; Freedman, ND; Huang, W; Anema, JG; Kahnoski, RJ; Lane, BR; Noyes, SL; Petillo, D; Teh, BT; Peters, U; White, E; Anderson, GL; Johnson, L; Luo, J; Buring, J; Lee, I; Chow, W; Moore, LE; Wood, C; Eisen, T; Henrion, M; Larkin, J; Barman, P; Leibovich, BC; Choueiri, TK; Mark Lathrop, G; Rothman, N; Deleuze, J; McKay, JD; Parker, AS; Wu, X; Houlston, RS; Brennan, P; Chanock, SJ and
(2017)
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Nature communications, 8 (1).
15724-.
ISSN 2041-1723
DOI: 10.1038/ncomms15724
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
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