Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
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Leandro M
Colli
;
Peng
Li
;
Joshua N
Sampson
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Behnoush
Abedi-Ardekani
;
Celine
Besse
;
Helene
Blanche
;
Anne
Boland
;
Laurie
Burdette
;
Amelie
Chabrier
;
Geoffroy
Durand
;
Florence
Le Calvez-Kelm
;
Egor
Prokhortchouk
;
Nivonirina
Robinot
;
Konstantin G
Skryabin
;
Magdalena B
Wozniak
;
Meredith
Yeager
;
Gordana
Basta-Jovanovic
;
Zoran
Dzamic
;
Lenka
Foretova
;
Ivana
Holcatova
;
Vladimir
Janout
;
Dana
Mates
;
Anush
Mukeriya
;
Stefan
Rascu
;
David
Zaridze
;
Vladimir
Bencko
;
Cezary
Cybulski
;
Eleonora
Fabianova
;
Viorel
Jinga
;
Jolanta
Lissowska
;
Jan
Lubinski
;
Marie
Navratilova
;
Peter
Rudnai
;
Neonila
Szeszenia-Dabrowska
;
Simone
Benhamou
;
Geraldine
Cancel-Tassin
;
Olivier
Cussenot
;
Laura
Baglietto
;
Heiner
Boeing
;
Kay-Tee
Khaw
;
Elisabete
Weiderpass
;
Borje
Ljungberg
;
Raviprakash T
Sitaram
;
Fiona
Bruinsma
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Susan J
Jordan
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Gianluca
Severi
;
Ingrid
Winship
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Kristian
Hveem
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Lars J
Vatten
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Tony
Fletcher
;
Kvetoslava
Koppova
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Susanna C
Larsson
;
Alicja
Wolk
;
Rosamonde E
Banks
;
Peter J
Selby
;
Douglas F
Easton
;
Paul
Pharoah
;
Gabriella
Andreotti
;
Laura E Beane
Freeman
;
Stella
Koutros
;
Demetrius
Albanes
;
Satu
Männistö
;
Stephanie
Weinstein
;
Peter E
Clark
;
Todd L
Edwards
;
Loren
Lipworth
;
Susan M
Gapstur
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Victoria L
Stevens
;
Hallie
Carol
;
Matthew L
Freedman
;
Mark M
Pomerantz
;
Eunyoung
Cho
;
Peter
Kraft
;
Mark A
Preston
;
Kathryn M
Wilson
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J
Michael Gaziano
;
Howard D
Sesso
;
Amanda
Black
;
Neal D
Freedman
;
Wen-Yi
Huang
;
John G
Anema
;
Richard J
Kahnoski
;
Brian R
Lane
;
Sabrina L
Noyes
;
David
Petillo
;
Bin Tean
Teh
;
Ulrike
Peters
;
Emily
White
;
Garnet L
Anderson
;
Lisa
Johnson
;
Juhua
Luo
;
Julie
Buring
;
I-Min
Lee
;
Wong-Ho
Chow
;
Lee E
Moore
;
Christopher
Wood
;
Timothy
Eisen
;
Marc
Henrion
;
James
Larkin
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Poulami
Barman
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Bradley C
Leibovich
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Toni K
Choueiri
;
G
Mark Lathrop
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Nathaniel
Rothman
;
Jean-Francois
Deleuze
;
James D
McKay
;
Alexander S
Parker
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Xifeng
Wu
;
Richard S
Houlston
;
Paul
Brennan
;
Stephen J
Chanock
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(2017)
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Nature communications, 8 (1).
15724-.
ISSN 2041-1723
DOI: 10.1038/ncomms15724
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
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