Genetic loci influencing kidney function and chronic kidney disease.
John C
Chambers
;
Weihua
Zhang
;
Graham M
Lord
;
Pim
van der Harst
;
Debbie A
Lawlor
;
Joban S
Sehmi
;
Daniel P
Gale
;
Mark N
Wass
;
Kourosh R
Ahmadi
;
Stephan JL
Bakker
;
+84 more...
Jacqui
Beckmann
;
Henk JG
Bilo
;
Murielle
Bochud
;
Morris J
Brown
;
Mark J
Caulfield
;
John MC
Connell
;
H Terence
Cook
;
Ioana
Cotlarciuc
;
George
Davey Smith
;
Ranil
de Silva
;
Guohong
Deng
;
Olivier
Devuyst
;
Lambert D
Dikkeschei
;
Nada
Dimkovic
;
Mark
Dockrell
;
Anna
Dominiczak
;
Shah
Ebrahim
;
Thomas
Eggermann
;
Martin
Farrall
;
Luigi
Ferrucci
;
Jurgen
Floege
;
Nita G
Forouhi
;
Ron T
Gansevoort
;
Xijin
Han
;
Bo
Hedblad
;
Jaap J
Homan van der Heide
;
Bouke G
Hepkema
;
Maria
Hernandez-Fuentes
;
Elina
Hypponen
;
Toby
Johnson
;
Paul E
de Jong
;
Nanne
Kleefstra
;
Vasiliki
Lagou
;
Marta
Lapsley
;
Yun
Li
;
Ruth JF
Loos
;
Jian'an
Luan
;
Karin
Luttropp
;
Céline
Maréchal
;
Olle
Melander
;
Patricia B
Munroe
;
Louise
Nordfors
;
Afshin
Parsa
;
Leena
Peltonen
;
Brenda W
Penninx
;
Esperanza
Perucha
;
Anneli
Pouta
;
Inga
Prokopenko
;
Paul J
Roderick
;
Aimo
Ruokonen
;
Nilesh J
Samani
;
Serena
Sanna
;
Martin
Schalling
;
David
Schlessinger
;
Georg
Schlieper
;
Marc AJ
Seelen
;
Alan R
Shuldiner
;
Marketa
Sjögren
;
Johannes H
Smit
;
Harold
Snieder
;
Nicole
Soranzo
;
Timothy D
Spector
;
Peter
Stenvinkel
;
Michael JE
Sternberg
;
Ramasamyiyer
Swaminathan
;
Toshiko
Tanaka
;
Lielith J
Ubink-Veltmaat
;
Manuela
Uda
;
Peter
Vollenweider
;
Chris
Wallace
;
Dawn
Waterworth
;
Klaus
Zerres
;
Gerard
Waeber
;
Nicholas J
Wareham
;
Patrick H
Maxwell
;
Mark I
McCarthy
;
Marjo-Riitta
Jarvelin
;
Vincent
Mooser
;
Goncalo R
Abecasis
;
Liz
Lightstone
;
James
Scott
;
Gerjan
Navis
;
Paul
Elliott
;
Jaspal S
Kooner
;
(2010)
Genetic loci influencing kidney function and chronic kidney disease.
Nature genetics, 42 (5).
pp. 373-375.
ISSN 1061-4036
DOI: 10.1038/ng.566
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
| Item Type | Article |
|---|---|
| ISI | 277179500005 |
| Date Deposited | 17 Oct 2011 14:36 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748585 (OA Location)
- 10.1038/ng.566 (DOI)
- 20383145 (PubMed)