Roberts, Lindi; Passmore, Jo-Ann S; Williamson, Carolyn; Little, Francesca; Bebell, Lisa M; Mlisana, Koleka; Burgers, Wendy A; van Loggerenberg, Francois; Walzl, Gerhard; Djoba Siawaya, Joel F; +2 more... Karim, Quarraisha Abdool; Karim, Salim S Abdool; (2010) Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS (London, England), 24 (6). pp. 819-831. ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0b013e3283367836
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression. Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown. OBJECTIVES: To identify cytokine biomarkers measurable in plasma during acute HIV-1 infection that predict HIV disease progression. DESIGN: Study including 40 South African women who became infected with HIV-1 and were followed longitudinally from the time of infection. METHODS: The concentrations of 30 cytokines in plasma from women with acute HIV-1 infection were measured and associations between cytokine levels and both viral load set point 12 months postinfection and time taken for CD4 cell counts to fall below 350 cells/microl were determined using multivariate and Cox proportional hazards regression. RESULTS: We found that the concentrations of five plasma cytokines, IL-12p40, IL-12p70, IFN-gamma, IL-7 and IL-15 in women with acute infection predicted 66% of the variation in viral load set point 12 months postinfection. IL-12p40, IL-12p70 and IFN-gamma were significantly associated with lower viral load, whereas IL-7 and IL-15 were associated with higher viral load. Plasma concentrations of IL-12p40 and granulocyte-macrophage colony-stimulating factor during acute infection were associated with maintenance of CD4 cell counts above 350 cells/microl, whereas IL-1alpha, eotaxin and IL-7 were associated with more rapid CD4 loss. CONCLUSION: A small panel of plasma cytokines during acute HIV-1 infection was predictive of long-term HIV disease prognosis in this group of South African women.
Item Type | Article |
---|---|
Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
PubMed ID | 20224308 |
ISI | 275636100004 |
Related URLs |
Download
Filename: nihms-254468.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
Download