Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Crawford, Hayley;
Prado, Julia G;
Leslie, Alasdair;
Hué, Stéphane;
Honeyborne, Isobella;
Reddy, Sharon;
van der Stok, Mary;
Mncube, Zenele;
Brander, Christian;
Rousseau, Christine;
+9 more...Mullins, James I;
Kaslow, Richard;
Goepfert, Paul;
Allen, Susan;
Hunter, Eric;
Mulenga, Joseph;
Kiepiela, Photini;
Walker, Bruce D;
Goulder, Philip JR;
(2007)
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Journal of virology, 81 (15).
pp. 8346-8351.
ISSN 0022-538X
DOI: https://doi.org/10.1128/JVI.00465-07
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HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
