Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients.
Li
Xu
;
Stéphane
Hué
;
Stephen
Taylor
;
Daina
Ratcliffe
;
Judith A
Workman
;
Susan
Jackson
;
Patricia A
Cane
;
Deenan
Pillay
;
(2002)
Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients.
AIDS (London, England), 16 (12).
pp. 1684-1686.
ISSN 0269-9370
DOI: 10.1097/00002030-200208160-00016
In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.
| Item Type | Article |
|---|---|
| ISI | 177561900015 |
| Date Deposited | 28 Feb 2017 02:00 |