%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Breno S. Kliemann, Anna S. Levin, M. Luísa Moura, Icaro Boszczowski, James J. Lewis
Socioeconomic Determinants of Antibiotic Consumption in the State of São Paulo, Brazil: The Effect of Restricting Over-The-Counter Sales
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref005)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref004)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref005)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref005)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref007)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref008)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref009)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref011)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref012)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref013)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref018)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref019)>>
endobj
34 0 obj
<>/Border[0 0 0]/A 35 0 R>>
endobj
35 0 obj
<>
endobj
15 0 obj
[36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R]
endobj
36 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 594.1142 m
199.9998 594.1142 l
199.9998 594.6143 l
575.9997 594.6143 l
f*
0.83 0.64 0.02 0 k
513.5244 523.8992 m
518.2866 523.8992 l
h
f*
267.6472 497.9339 m
272.3528 497.9339 l
h
f*
362.7213 484.8945 m
367.4835 484.8945 l
h
f*
557.9717 471.9118 m
562.7339 471.9118 l
h
f*
287.3764 445.9465 m
292.0819 445.9465 l
h
f*
389.9339 445.9465 m
394.6961 445.9465 l
h
f*
309.1465 367.937 m
313.9087 367.937 l
h
f*
265.9465 315.9496 m
270.7087 315.9496 l
h
f*
272.9764 315.9496 m
277.7386 315.9496 l
h
f*
483.0236 302.9102 m
487.7858 302.9102 l
h
f*
283.748 276.9449 m
288.5102 276.9449 l
h
f*
453.3165 263.9055 m
458.0787 263.9055 l
h
f*
329.2157 237.9402 m
333.978 237.9402 l
h
f*
339.137 237.9402 m
348.6614 237.9402 l
h
f*
256.989 159.9307 m
266.4567 159.9307 l
h
f*
506.8346 107.9433 m
516.3591 107.9433 l
h
f*
521.5181 107.9433 m
530.9858 107.9433 l
h
f*
462.8409 94.9039 m
472.3654 94.9039 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(consumption)Tj
5.8244 0 Td
(were)Tj
2.3632 0 Td
(higher)Tj
2.9599 0 Td
(human)Tj
3.2464 0 Td
(development)Tj
5.8782 0 Td
(index,)Tj
2.8585 0 Td
(percentage)Tj
5.162 0 Td
(of)Tj
1.0503 0 Td
(urban)Tj
2.7451 0 Td
(population,)Tj
5.0427 0 Td
(den-)Tj
-37.1307 -1.474 Td
(sity)Tj
1.7007 0 Td
(of)Tj
1.0444 0 Td
(private)Tj
3.1807 0 Td
(health)Tj
2.9063 0 Td
(establishments)Tj
6.6002 0 Td
(,)Tj
0.4894 0 Td
(life)Tj
1.474 0 Td
(expectancy)Tj
5.2276 0 Td
(and)Tj
1.8619 0 Td
(percentage)Tj
5.1621 0 Td
(of)Tj
1.0443 0 Td
(females;)Tj
3.9625 0 Td
(lower)Tj
2.5721 0 Td
(illiter-)Tj
-37.2262 -1.474 Td
(acy)Tj
1.7604 0 Td
(levels)Tj
2.7392 0 Td
(and)Tj
1.8678 0 Td
(lower)Tj
2.5781 0 Td
(percentage)Tj
5.162 0 Td
(of)Tj
1.0503 0 Td
(population)Tj
4.7682 0 Td
(between)Tj
3.9565 0 Td
(5)Tj
0.7639 0 Td
(and)Tj
1.8678 0 Td
(15)Tj
1.3189 0 Td
(years)Tj
2.6377 0 Td
(old.)Tj
1.8142 0 Td
(A)Tj
0.8832 0 Td
(higher)Tj
-33.1682 -1.474 Td
(percentage)Tj
5.162 0 Td
(of)Tj
1.0503 0 Td
(females)Tj
3.682 0 Td
(was)Tj
1.9813 0 Td
(associated)Tj
4.9472 0 Td
(with)Tj
1.9753 0 Td
(a)Tj
0.7698 0 Td
(stronger)Tj
3.8491 0 Td
(effect)Tj
2.6437 0 Td
(of)Tj
1.0443 0 Td
(the)Tj
1.5994 0 Td
(law.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 638.5889 cm
BT
/F3 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 621.6377 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(SSP)Tj
2.208 0 Td
(had)Tj
1.8679 0 Td
(similar)Tj
3.0673 0 Td
(antibiotic)Tj
4.1117 0 Td
(consumption)Tj
5.8304 0 Td
(levels)Tj
2.7392 0 Td
(as)Tj
1.2651 0 Td
(the)Tj
1.5934 0 Td
(whole)Tj
2.7988 0 Td
(country)Tj
3.4672 0 Td
(of)Tj
1.0444 0 Td
(Brazil,)Tj
2.9659 0 Td
(and)Tj
1.8679 0 Td
(they)Tj
2.0887 0 Td
(were)Tj
-36.9159 -1.474 Td
(effectively)Tj
4.6189 0 Td
(reduced)Tj
3.7895 0 Td
(by)Tj
1.2651 0 Td
(the)Tj
1.5934 0 Td
(policy.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 541.9842 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 524.9763 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Although)Tj
4.0024 0 Td
(infectious)Tj
4.1329 0 Td
(diseases)Tj
3.3789 0 Td
(continue)Tj
3.7644 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(a)Tj
0.652 0 Td
(major)Tj
2.6078 0 Td
(cause)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(death)Tj
2.4321 0 Td
(worldwide)Tj
4.4617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(],)Tj
1.5987 0 Td
(the)Tj
1.4683 0 Td
(develop-)Tj
-34.0778 -1.2982 Td
(ment)Tj
2.3073 0 Td
(of)Tj
1.0148 0 Td
(new)Tj
1.8766 0 Td
(antibiotics)Tj
4.3993 0 Td
(is)Tj
0.8504 0 Td
(in)Tj
1.0318 0 Td
(decline,)Tj
3.3052 0 Td
(and)Tj
1.7348 0 Td
(no)Tj
1.2755 0 Td
(new)Tj
1.8766 0 Td
(therapeutic)Tj
4.7281 0 Td
(classes)Tj
2.8347 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(discovered)Tj
-31.4133 -1.2983 Td
(since)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(1970s.)Tj
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(])Tj
1.372 0 Td
(The)Tj
1.7858 0 Td
(occurrence)Tj
4.6601 0 Td
(of)Tj
1.0148 0 Td
(antimicrobial)Tj
5.6126 0 Td
(resistance)Tj
4.1329 0 Td
(\(AMR\))Tj
3.0954 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(community)Tj
4.8869 0 Td
(set-)Tj
-35.4895 -1.3039 Td
(ting)Tj
1.7971 0 Td
(is)Tj
0.8504 0 Td
(becoming)Tj
4.1782 0 Td
(increasingly)Tj
5.0343 0 Td
(common.)Tj
4.0706 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
1.3719 0 Td
(Overuse)Tj
3.532 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3993 0 Td
(in)Tj
1.0318 0 Td
(clinical)Tj
3.0784 0 Td
(settings)Tj
3.2428 0 Td
(is)Tj
0.8504 0 Td
(cur-)Tj
-34.452 -1.2983 Td
(rently)Tj
2.5625 0 Td
(recognised)Tj
4.5354 0 Td
(as)Tj
1.0148 0 Td
(one)Tj
1.7007 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(main)Tj
2.2903 0 Td
(drivers)Tj
2.9991 0 Td
(of)Tj
1.0148 0 Td
(emerging)Tj
4.0025 0 Td
(antibiotic)Tj
4.0365 0 Td
(resistance)Tj
4.1329 0 Td
(worldwide.)Tj
4.6828 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(])Tj
-35.4555 -1.2982 Td
(Misuse)Tj
3.05 0 Td
(of)Tj
1.0148 0 Td
(antibiotics,)Tj
4.6261 0 Td
(by)Tj
1.1792 0 Td
(erroneous)Tj
4.2633 0 Td
(prescribing)Tj
4.7395 0 Td
(or)Tj
1.0998 0 Td
(noncompliance)Tj
6.4346 0 Td
(may)Tj
1.9276 0 Td
(further)Tj
3.0274 0 Td
(contribute)Tj
4.3936 0 Td
(to)Tj
-35.7559 -1.2983 Td
(antibiotic)Tj
4.0365 0 Td
(resistance.)Tj
4.3596 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
1.372 0 Td
(Goossens)Tj
/F10 1 Tf
4.0081 0 Td
[()8()]TJ
0.9071 0 Td
[()11()]TJ
/F7 1 Tf
(.)Tj
1.1679 0 Td
(\(2005\))Tj
2.8006 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
1.3776 0 Td
(analysed)Tj
3.651 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(outpatient)Tj
4.337 0 Td
(antibiotic)Tj
4.0422 0 Td
(use)Tj
-35.4498 -1.3039 Td
(in)Tj
1.0318 0 Td
(26)Tj
1.1735 0 Td
(European)Tj
4.1215 0 Td
(countries,)Tj
4.1726 0 Td
(finding)Tj
3.1294 0 Td
(an)Tj
1.2019 0 Td
(ecological)Tj
4.1669 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5263 0 Td
(antibiotic)Tj
4.0422 0 Td
(consumption)Tj
-31.1922 -1.2983 Td
(and)Tj
1.7291 0 Td
(rates)Tj
2.1089 0 Td
(of)Tj
1.0148 0 Td
(AMRboth)Tj
5.1817 0 Td
(were)Tj
2.1203 0 Td
(higher)Tj
2.8063 0 Td
(in)Tj
1.0318 0 Td
(France)Tj
2.948 0 Td
(and)Tj
1.7348 0 Td
(Southern)Tj
3.9005 0 Td
(European)Tj
4.1159 0 Td
(countries)Tj
3.9458 0 Td
(and)Tj
1.7347 0 Td
(lower)Tj
-34.3726 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(Netherlands)Tj
5.1136 0 Td
(and)Tj
1.7348 0 Td
(Northern)Tj
4.0025 0 Td
(European)Tj
4.1159 0 Td
(countries.)Tj
-16.2764 -1.304 Td
(Different)Tj
3.8607 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0091 0 Td
(antibiotic)Tj
4.0365 0 Td
(use)Tj
1.5251 0 Td
(across)Tj
2.6758 0 Td
(regions)Tj
3.1578 0 Td
(may)Tj
1.9276 0 Td
(occur)Tj
2.4661 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0205 0 Td
(differences)Tj
4.5637 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(incidence)Tj
-33.7434 -1.2982 Td
(of)Tj
1.0147 0 Td
(infectious)Tj
4.1329 0 Td
(diseases,)Tj
3.6 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(availability)Tj
4.5298 0 Td
(of)Tj
1.0148 0 Td
(antibiotics,)Tj
4.6261 0 Td
(in)Tj
1.0374 0 Td
(patient-related)Tj
6.0775 0 Td
(factors,)Tj
3.1294 0 Td
(in)Tj
1.0375 0 Td
(antibiotic)Tj
-32.7059 -1.2983 Td
(prescribing)Tj
4.7394 0 Td
(or)Tj
1.0999 0 Td
(dispensing.)Tj
4.7338 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
1.372 0 Td
(These)Tj
2.5681 0 Td
(factors)Tj
2.9027 0 Td
(are)Tj
1.4513 0 Td
(often)Tj
2.2847 0 Td
(inter-related)Tj
5.2044 0 Td
(and)Tj
1.7291 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1508 0 Td
(affected)Tj
3.3279 0 Td
(by)Tj
1.1792 0 Td
(sev-)Tj
-35.6709 -1.3039 Td
(eral)Tj
1.6951 0 Td
(distal)Tj
2.3527 0 Td
(determinants.)Tj
5.7656 0 Td
(For)Tj
1.6271 0 Td
(instance,)Tj
3.7531 0 Td
(cultural)Tj
3.2938 0 Td
(aspects)Tj
3.0387 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(pressure)Tj
3.5773 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(pharmaceutical)Tj
-30.784 -1.2983 Td
(companies)Tj
4.5183 0 Td
(may)Tj
1.9276 0 Td
(act)Tj
1.3776 0 Td
(through)Tj
3.4469 0 Td
(raising)Tj
2.931 0 Td
(a)Tj
0.6577 0 Td
(patient's)Tj
3.5829 0 Td
(demand)Tj
3.498 0 Td
(for)Tj
1.3889 0 Td
(antibiotics,)Tj
4.6205 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(patient's)Tj
-31.1525 -1.2982 Td
(demand)Tj
3.4979 0 Td
(for)Tj
1.3889 0 Td
(antibiotics)Tj
4.3994 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(shown)Tj
2.8517 0 Td
(to)Tj
1.0261 0 Td
(influence)Tj
3.9118 0 Td
(the)Tj
1.474 0 Td
(doctor's)Tj
3.4299 0 Td
(decision)Tj
3.5433 0 Td
(on)Tj
1.2756 0 Td
(whether)Tj
3.4752 0 Td
(to)Tj
1.0261 0 Td
(pre-)Tj
-34.9622 -1.2983 Td
(scribe)Tj
2.5738 0 Td
(it)Tj
0.7823 0 Td
(or)Tj
1.0999 0 Td
(not.)Tj
1.7971 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
2.0807 0 Td
(Patient-related)Tj
6.1228 0 Td
(factors)Tj
2.9026 0 Td
(are)Tj
1.4457 0 Td
(often)Tj
2.2904 0 Td
(related)Tj
2.9423 0 Td
(to)Tj
1.0261 0 Td
(knowledge)Tj
4.5411 0 Td
(about)Tj
2.4945 0 Td
(antibiotics')Tj
-32.0993 -1.3039 Td
(risks)Tj
2.0749 0 Td
(and)Tj
1.7291 0 Td
(benefits,)Tj
3.566 0 Td
(relationship)Tj
4.9889 0 Td
(with)Tj
1.9956 0 Td
(physicians,)Tj
4.6091 0 Td
(and)Tj
1.7291 0 Td
(economic)Tj
4.1386 0 Td
(factors.)Tj
3.1294 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
1.3776 0 Td
(Additionally,)Tj
5.4539 0 Td
(differ-)Tj
-34.7922 -1.2983 Td
(ences)Tj
2.398 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(incidence)Tj
4.0705 0 Td
(of)Tj
1.0148 0 Td
(infectious)Tj
4.1329 0 Td
(disease)Tj
3.0217 0 Td
(are)Tj
1.4456 0 Td
(the)Tj
1.4684 0 Td
(main)Tj
2.2904 0 Td
(reason)Tj
2.8686 0 Td
(for)Tj
1.3833 0 Td
(seasonal)Tj
3.5376 0 Td
(variations)Tj
4.1612 0 Td
(in)Tj
1.0375 0 Td
(anti-)Tj
-35.3364 -1.2982 Td
(biotic)Tj
2.4888 0 Td
(consumption)Tj
5.5445 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(];)Tj
1.6044 0 Td
(and,)Tj
1.9559 0 Td
(in)Tj
1.0318 0 Td
(some)Tj
2.33 0 Td
(low-income)Tj
5.0003 0 Td
(countries,)Tj
4.1726 0 Td
(areas)Tj
2.245 0 Td
(may)Tj
1.9276 0 Td
(have)Tj
2.0579 0 Td
(lower)Tj
2.4548 0 Td
(antibiotic)Tj
-32.8136 -1.304 Td
(consumption)Tj
5.5445 0 Td
(rates)Tj
2.1089 0 Td
(because)Tj
3.3166 0 Td
(of)Tj
1.0148 0 Td
(lack)Tj
1.8198 0 Td
(of)Tj
1.0148 0 Td
(availability)Tj
4.5354 0 Td
(of)Tj
1.0148 0 Td
(antibiotics.)Tj
4.6204 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(])Tj
1.3777 0 Td
(Many)Tj
2.5511 0 Td
(socioeconomic)Tj
6.2022 0 Td
(deter-)Tj
-35.121 -1.2982 Td
(minants)Tj
3.4979 0 Td
(\(SED\),)Tj
2.9026 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(income)Tj
3.2088 0 Td
(and)Tj
1.7292 0 Td
(education)Tj
4.1782 0 Td
(levels,)Tj
2.6022 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(shown)Tj
2.8517 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(possible)Tj
3.4072 0 Td
(predic-)Tj
-33.8114 -1.2983 Td
(tors)Tj
1.7574 0 Td
(of)Tj
1.0148 0 Td
(antibiotic)Tj
4.0365 0 Td
(consumption.)Tj
5.7713 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
-0.005 Tc
-11.3838 -1.3039 Td
(In)Tj
1.1111 0 Td
(most)Tj
2.1997 0 Td
(Latin)Tj
2.3017 0 Td
(American)Tj
4.1839 0 Td
(countries)Tj
3.9402 0 Td
(\(LAC\),)Tj
3.0047 0 Td
(antibiotics)Tj
4.388 0 Td
(are)Tj
1.4456 0 Td
(dispensed)Tj
4.1669 0 Td
(only)Tj
1.9729 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(medical)Tj
3.3562 0 Td
(pre-)Tj
-35.9147 -1.2983 Td
(scription)Tj
3.7587 0 Td
(in)Tj
1.0261 0 Td
(the)Tj
1.457 0 Td
(public)Tj
2.6929 0 Td
(sector.)Tj
2.8119 0 Td
(In)Tj
1.0942 0 Td
(private)Tj
2.9707 0 Td
(pharmacies,)Tj
5.006 0 Td
(however,)Tj
3.8154 0 Td
(it)Tj
0.7767 0 Td
(was)Tj
1.6837 0 Td
(possible)Tj
3.3902 0 Td
(to)Tj
1.0148 0 Td
(buy)Tj
1.6951 0 Td
(them)Tj
2.2791 0 Td
(with-)Tj
-35.4725 -1.2982 Td
(out)Tj
1.5477 0 Td
(prescriptionsi.e.,)Tj
7.7272 0 Td
(over-the-counter)Tj
7.0128 0 Td
(\(OTC\).)Tj
3.1408 0 Td
(While)Tj
2.6419 0 Td
(in)Tj
1.0374 0 Td
(some)Tj
2.3244 0 Td
(settings)Tj
3.2372 0 Td
(OTC)Tj
2.2393 0 Td
(sales)Tj
2.0353 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
-34.8715 -1.304 Td
(essential)Tj
3.5716 0 Td
(to)Tj
1.0261 0 Td
(allow)Tj
2.3301 0 Td
(the)Tj
1.4683 0 Td
(access)Tj
2.6419 0 Td
(to)Tj
1.0205 0 Td
(medicines)Tj
4.2746 0 Td
(for)Tj
1.3833 0 Td
(people)Tj
2.8459 0 Td
(who)Tj
1.9389 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5704 0 Td
(have)Tj
2.0523 0 Td
(access)Tj
2.6419 0 Td
(to)Tj
1.0261 0 Td
(physicians,)Tj
4.5921 0 Td
(the)Tj
-35.6369 -1.2982 Td
(possibility)Tj
4.2632 0 Td
(of)Tj
1.0092 0 Td
(self-medication)Tj
6.3949 0 Td
(increases)Tj
3.8211 0 Td
(the)Tj
1.4683 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0091 0 Td
(overuse)Tj
3.2825 0 Td
(and)Tj
1.7292 0 Td
(misuse)Tj
2.9763 0 Td
(of)Tj
1.0091 0 Td
(antibiotics)Tj
4.388 0 Td
(and)Tj
1.7292 0 Td
(hence)Tj
-34.7922 -1.2983 Td
(of)Tj
1.0091 0 Td
(resistance.)Tj
4.3483 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
1.8482 0 Td
(Some)Tj
2.4434 0 Td
(LAC)Tj
2.0976 0 Td
(have,)Tj
2.2848 0 Td
(in)Tj
1.0318 0 Td
(recent)Tj
2.7042 0 Td
(years,)Tj
2.4831 0 Td
(promoted)Tj
4.1839 0 Td
(policies)Tj
3.2258 0 Td
(enforcing)Tj
4.0536 0 Td
(their)Tj
2.1033 0 Td
(regula-)Tj
-33.8171 -1.2982 Td
(tion)Tj
1.8368 0 Td
(on)Tj
1.2699 0 Td
(antibiotic)Tj
4.0308 0 Td
(sales)Tj
2.041 0 Td
(and)Tj
1.7291 0 Td
(prohibiting)Tj
4.7508 0 Td
(OTC)Tj
2.2394 0 Td
(sales.)Tj
2.262 0 Td
(Chile)Tj
2.3414 0 Td
(abolished)Tj
4.0139 0 Td
(OTC)Tj
2.2393 0 Td
(sales)Tj
2.0409 0 Td
(in)Tj
1.0319 0 Td
(1999;)Tj
2.3414 0 Td
(and)Tj
-34.1686 -1.304 Td
(Colombia)Tj
4.1612 0 Td
(did)Tj
1.542 0 Td
(the)Tj
1.4627 0 Td
(same)Tj
2.2564 0 Td
(in)Tj
1.0318 0 Td
(2005,)Tj
2.347 0 Td
(but)Tj
1.5477 0 Td
(only)Tj
1.9729 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(capital)Tj
2.8346 0 Td
(district)Tj
3.0274 0 Td
(of)Tj
1.0091 0 Td
(Bogota)Tj
0 Tc
2.3754 0.0511 Td
()Tj
-0.005 Tc
0.4082 -0.0511 Td
(.)Tj
0.4479 0 Td
(Venezuela)Tj
4.3426 0 Td
(prohibited)Tj
-33.2671 -1.2982 Td
(OTC)Tj
2.2393 0 Td
(sales)Tj
2.0409 0 Td
(nationwide)Tj
4.7112 0 Td
(for)Tj
1.3833 0 Td
(some)Tj
2.3301 0 Td
(classes)Tj
2.8232 0 Td
(of)Tj
1.0092 0 Td
(antibiotics)Tj
4.388 0 Td
(\(macrolides,)Tj
5.159 0 Td
(quinolones)Tj
4.6488 0 Td
(and)Tj
1.7291 0 Td
(third-gener-)Tj
-32.4621 -1.2983 Td
(ation)Tj
2.2677 0 Td
(cephalosporins\))Tj
6.5593 0 Td
(in)Tj
1.0318 0 Td
(2006;)Tj
2.3414 0 Td
(and)Tj
1.7291 0 Td
(Mexico)Tj
3.1918 0 Td
(prohibited)Tj
4.4277 0 Td
(all)Tj
1.1395 0 Td
(OTC)Tj
2.2394 0 Td
(sales)Tj
2.0409 0 Td
(in)Tj
1.0318 0 Td
(2010.)Tj
2.3471 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
-0.004 Tc
-29.1513 -1.3039 Td
(Brazil)Tj
2.5341 0 Td
(also)Tj
1.7688 0 Td
(issued)Tj
2.6873 0 Td
(a)Tj
0.6519 0 Td
(law)Tj
1.5874 0 Td
(abolishing)Tj
4.3483 0 Td
(OTC)Tj
2.2394 0 Td
(sales)Tj
2.0466 0 Td
(in)Tj
1.0375 0 Td
(October)Tj
3.4979 0 Td
(2010.)Tj
2.3471 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(])Tj
1.8538 0 Td
(It)Tj
0.8561 0 Td
(enforced)Tj
3.7303 0 Td
(the)Tj
1.474 0 Td
(require-)Tj
-33.8567 -1.2983 Td
(ment)Tj
2.3073 0 Td
(of)Tj
1.0148 0 Td
(medical)Tj
3.3619 0 Td
(prescriptions)Tj
5.4538 0 Td
(for)Tj
1.389 0 Td
(antibiotic)Tj
4.0365 0 Td
(sales)Tj
2.0466 0 Td
(in)Tj
1.0375 0 Td
(private)Tj
2.982 0 Td
(pharmacies,)Tj
5.0286 0 Td
(demanding)Tj
4.7792 0 Td
(a)Tj
0.652 0 Td
(copy)Tj
2.126 0 Td
(of)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Antibiotic)Tj
4.2023 0 Td
(Consum)Tj
3.6639 0 Td
(ption)Tj
2.3456 0 Td
(Determinan)Tj
5.0812 0 Td
(ts)Tj
0.985 0 Td
(in)Tj
0.978 0 Td
(S)Tj
/F5 1 Tf
[( m)]TJ
/F0 1 Tf
(o)Tj
1.9701 0 Td
(Paulo)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0167)Tj
3.5434 0 Td
(885)Tj
2.6362 0 Td
(December)Tj
4.7622 0 Td
(12,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(14)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
36 707.6409 m
102.0472 707.6409 l
h
f*
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(http://www)Tj
4.1102 0 Td
(.mrc.ac.uk)Tj
3.8906 0 Td
(/)Tj
0 g
(.)Tj
0.7016 0 Td
(The)Tj
1.5874 0 Td
(funders)Tj
3.0473 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
-17.7095 -1.3748 Td
(study)Tj
2.2677 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
3.7346 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4158 0 Td
(decision)Tj
-15.6969 -1.3748 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9425 0 Td
(the)Tj
1.3748 0 Td
(manuscript.)Tj
/F8 1 Tf
-11.8559 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
BT
10.3394 -6.2504 Td
(exist.)Tj
ET
Q
endstream
endobj
52 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 54 0 R/Contents 55 0 R/TrimBox[0 0 612 792]>>
endobj
54 0 obj
[56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref012)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref020)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref007)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref021)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref022)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref026)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref022)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref026)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpone.0167885.ref027)>>
endobj
55 0 obj
[65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R]
endobj
65 0 obj
<>stream
q
0.83 0.64 0.02 0 k
519.3638 693.2976 m
528.8882 693.2976 l
h
f*
252.2268 680.315 m
261.6945 680.315 l
h
f*
406.7717 641.3102 m
411.5339 641.3102 l
h
f*
486.085 576.3402 m
495.6094 576.3402 l
h
f*
395.3764 550.3181 m
404.9008 550.3181 l
h
f*
410.0598 550.3181 m
419.5843 550.3181 l
h
f*
442.9417 537.3354 m
452.4661 537.3354 l
h
f*
463.011 472.3087 m
472.5354 472.3087 l
h
f*
501.222 81.9213 m
510.6898 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(the)Tj
1.4683 0 Td
(prescription)Tj
5.091 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(retained)Tj
3.5149 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(pharmacy)Tj
4.2009 0 Td
(for)Tj
1.389 0 Td
(every)Tj
2.3471 0 Td
(sale.)Tj
1.9105 0 Td
(Before)Tj
2.812 0 Td
(this)Tj
1.6724 0 Td
(intervention,)Tj
5.4028 0 Td
(46%)Tj
1.9275 0 Td
(of)Tj
-36.4192 -1.3039 Td
(antibiotic)Tj
4.0365 0 Td
(sales)Tj
2.0466 0 Td
(in)Tj
1.0318 0 Td
(Brazil)Tj
2.5341 0 Td
(were)Tj
2.1203 0 Td
(reported)Tj
3.6624 0 Td
(to)Tj
1.0261 0 Td
(occur)Tj
2.4718 0 Td
(without)Tj
3.3335 0 Td
(a)Tj
0.652 0 Td
(medical)Tj
3.3618 0 Td
(prescription.)Tj
5.3178 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
1.8539 0 Td
(Wirtz)Tj
/F10 1 Tf
-33.4486 -1.2982 Td
[()8()]TJ
0.907 0 Td
[()11()]TJ
/F7 1 Tf
(.)Tj
1.1679 0 Td
(\(2010\))Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(],)Tj
2.0749 0 Td
(in)Tj
1.0375 0 Td
(an)Tj
1.2019 0 Td
(analysis)Tj
3.3278 0 Td
(of)Tj
1.0148 0 Td
(retail)Tj
2.2564 0 Td
(sales)Tj
2.0466 0 Td
(between)Tj
3.5263 0 Td
(1997)Tj
2.1259 0 Td
(and)Tj
1.7292 0 Td
(2007,)Tj
2.347 0 Td
(reported)Tj
3.6624 0 Td
(that)Tj
1.7745 0 Td
(Brazil)Tj
2.5341 0 Td
(had)Tj
-35.5405 -1.2983 Td
(the)Tj
1.4683 0 Td
(lowest)Tj
2.7382 0 Td
(antibiotic)Tj
4.0422 0 Td
(consumption)Tj
5.5445 0 Td
(rate)Tj
1.7462 0 Td
(among)Tj
2.9933 0 Td
(eight)Tj
2.1997 0 Td
(LAC,)Tj
2.3358 0 Td
(increasing)Tj
4.3256 0 Td
(from)Tj
2.2053 0 Td
(6.51)Tj
1.8766 0 Td
(to)Tj
1.0261 0 Td
(7.01)Tj
1.8708 0 Td
(defined)Tj
-34.3726 -1.2983 Td
(daily)Tj
2.1486 0 Td
(doses)Tj
2.3981 0 Td
(per)Tj
1.5364 0 Td
(1,000)Tj
2.347 0 Td
(inhabitants)Tj
4.7112 0 Td
(per)Tj
1.5307 0 Td
(day)Tj
1.6384 0 Td
(during)Tj
2.9253 0 Td
(this)Tj
1.6725 0 Td
(time)Tj
2.0296 0 Td
(period.)Tj
3.0614 0 Td
(In)Tj
1.1055 0 Td
(a)Tj
0.6576 0 Td
(review)Tj
2.8403 0 Td
(of)Tj
1.0148 0 Td
(global)Tj
2.6305 0 Td
(antibi-)Tj
-34.2479 -1.3039 Td
(otic)Tj
1.7121 0 Td
(consumption)Tj
5.5502 0 Td
(trends,)Tj
2.9763 0 Td
(Van)Tj
1.8936 0 Td
(Boeckel)Tj
/F10 1 Tf
3.3221 0 Td
[()8()]TJ
0.9071 0 Td
[()11()]TJ
/F7 1 Tf
(.)Tj
1.1679 0 Td
(\(2014\))Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
1.3719 0 Td
(noticed)Tj
3.2202 0 Td
(that,)Tj
2.0012 0 Td
(although)Tj
3.7531 0 Td
(being)Tj
2.4321 0 Td
(among)Tj
2.9933 0 Td
(the)Tj
-36.1074 -1.2982 Td
(countries)Tj
3.9458 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(lowest)Tj
2.7382 0 Td
(interval)Tj
3.2655 0 Td
(\(1)Tj
1.0375 0 Td
(to)Tj
1.0261 0 Td
(8)Tj
0.6917 0 Td
(standard)Tj
3.7247 0 Td
(units)Tj
2.2223 0 Td
(per)Tj
1.5307 0 Td
(person\))Tj
3.2882 0 Td
(of)Tj
1.0148 0 Td
(antibiotic)Tj
4.0422 0 Td
(consumption)Tj
-31.0335 -1.2983 Td
(level)Tj
2.0125 0 Td
(in)Tj
1.0375 0 Td
(2010,)Tj
2.3471 0 Td
(Brazil)Tj
2.5285 0 Td
(was)Tj
1.7007 0 Td
(in)Tj
1.0375 0 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(highest)Tj
3.0898 0 Td
(intervals)Tj
3.6226 0 Td
(of)Tj
1.0148 0 Td
(consumption)Tj
5.5446 0 Td
(compound)Tj
4.6034 0 Td
(annual)Tj
-32.7229 -1.3039 Td
(growth)Tj
3.0727 0 Td
(rate)Tj
1.7461 0 Td
(\(2.5)Tj
1.7348 0 Td
(to)Tj
1.0261 0 Td
(6\))Tj
1.0375 0 Td
(between)Tj
3.5263 0 Td
(2000)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(2010.)Tj
-14.8024 -1.2983 Td
(The)Tj
1.7858 0 Td
(Brazilian)Tj
3.7814 0 Td
(state)Tj
2.0352 0 Td
(of)Tj
1.0148 0 Td
(S)Tj
/F11 1 Tf
[()]TJ
/F7 1 Tf
(o)Tj
1.6328 0 Td
(Paulo)Tj
2.4944 0 Td
(\(SSP\))Tj
2.4095 0 Td
(is)Tj
0.8504 0 Td
(Brazil's)Tj
3.1067 0 Td
(most)Tj
2.2054 0 Td
(populous)Tj
3.9344 0 Td
(state,)Tj
2.2564 0 Td
(with)Tj
2.0012 0 Td
(41,262,199)Tj
4.4731 0 Td
(peo-)Tj
-35.1777 -1.2983 Td
(ple)Tj
1.4059 0 Td
(in)Tj
1.0375 0 Td
(2010,)Tj
2.3471 0 Td
(and)Tj
1.7291 0 Td
(its)Tj
1.1452 0 Td
(645)Tj
1.6497 0 Td
(municipalities)Tj
5.8847 0 Td
(are)Tj
1.4514 0 Td
(grouped)Tj
3.5602 0 Td
(in)Tj
1.0319 0 Td
(15)Tj
1.1735 0 Td
(meso-regions.)Tj
5.8507 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8538 0 Td
(There)Tj
2.5738 0 Td
(are,)Tj
1.6725 0 Td
(how-)Tj
-34.367 -1.3039 Td
(ever,)Tj
2.1146 0 Td
(few)Tj
1.6157 0 Td
(studies)Tj
2.9877 0 Td
(on)Tj
1.2756 0 Td
(variations)Tj
4.1612 0 Td
(in)Tj
1.0375 0 Td
(antibiotic)Tj
4.0365 0 Td
(use)Tj
1.5364 0 Td
(within)Tj
2.8119 0 Td
(SSP)Tj
1.7292 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(SED,)Tj
2.2281 0 Td
(with)Tj
1.9955 0 Td
(these)Tj
2.2564 0 Td
(studies)Tj
-33.6243 -1.2982 Td
(usually)Tj
3.0103 0 Td
(focusing)Tj
3.5943 0 Td
(on)Tj
1.2699 0 Td
(single)Tj
2.5229 0 Td
(or)Tj
1.0885 0 Td
(few)Tj
1.6044 0 Td
(municipalities.)Tj
6.1057 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(])Tj
3.3109 0 Td
(There)Tj
2.5682 0 Td
(are)Tj
1.44 0 Td
(also)Tj
1.7631 0 Td
(little)Tj
1.9899 0 Td
(data)Tj
1.9049 0 Td
(about)Tj
2.4831 0 Td
(the)Tj
1.4627 0 Td
(lev-)Tj
-36.1188 -1.2983 Td
(els)Tj
1.2415 0 Td
(and)Tj
1.7178 0 Td
(the)Tj
1.4627 0 Td
(evolution)Tj
3.9911 0 Td
(of)Tj
1.0035 0 Td
(AMR)Tj
2.4094 0 Td
(within)Tj
2.8063 0 Td
(SSP.)Tj
1.9446 0 Td
(Kiffer)Tj
/F10 1 Tf
2.5228 0 Td
[()8()]TJ
0.9014 0 Td
[()11()]TJ
/F7 1 Tf
(.)Tj
1.1565 0 Td
(\(2011\))Tj
2.795 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(])Tj
1.8425 0 Td
(showed)Tj
3.2428 0 Td
(the)Tj
1.457 0 Td
(emergence)Tj
4.5354 0 Td
(of)Tj
1.0034 0 Td
(cip-)Tj
-36.0337 -1.3039 Td
(rofloxacin-resistant)Tj
/F10 1 Tf
7.9879 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F10 1 Tf
0.9978 0 Td
[()7()10()12()]TJ
/F7 1 Tf
1.5591 0 Td
(clusters)Tj
3.2314 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(spatially)Tj
3.4753 0 Td
(correlated)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(areas)Tj
2.245 0 Td
(of)Tj
1.0148 0 Td
(higher)Tj
2.8006 0 Td
(antibiotic)Tj
-30.7613 -1.2983 Td
(consumption)Tj
5.5445 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.4684 0 Td
(city)Tj
1.6667 0 Td
(of)Tj
1.0148 0 Td
(S)Tj
/F11 1 Tf
[()]TJ
/F7 1 Tf
(o)Tj
1.6384 0 Td
(Pauloresistant)Tj
6.7805 0 Td
(cluster)Tj
2.8686 0 Td
(emergence)Tj
4.5411 0 Td
(was)Tj
1.7008 0 Td
(related)Tj
2.9423 0 Td
(to)Tj
1.0261 0 Td
(an)Tj
1.2019 0 Td
(anti-)Tj
-35.206 -1.2982 Td
(biotic)Tj
2.4888 0 Td
(use)Tj
1.5307 0 Td
(density)Tj
3.101 0 Td
(of)Tj
1.0148 0 Td
(5)Tj
0.6974 0 Td
(to)Tj
1.0261 0 Td
(9)Tj
0.6916 0 Td
(defined)Tj
3.2315 0 Td
(daily)Tj
2.1487 0 Td
(doses)Tj
2.3981 0 Td
(per)Tj
1.5307 0 Td
(1,000)Tj
2.347 0 Td
(inhabitants-day.)Tj
6.7068 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2563 0 Td
(study,)Tj
-33.749 -1.2983 Td
(out)Tj
1.5533 0 Td
(of)Tj
1.0148 0 Td
(4,372)Tj
2.3471 0 Td
(cases)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(urinary)Tj
3.1918 0 Td
(tract)Tj
2.0466 0 Td
(infection)Tj
3.7928 0 Td
(caused)Tj
2.9196 0 Td
(by)Tj
/F10 1 Tf
1.1792 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F10 1 Tf
0.9922 0 Td
[()7()10()12()]TJ
/F7 1 Tf
(,)Tj
1.7858 0 Td
(identified)Tj
4.0592 0 Td
(from)Tj
2.2053 0 Td
(two)Tj
1.7121 0 Td
(outpatient)Tj
-32.0369 -1.3039 Td
(centres,)Tj
3.2938 0 Td
(723)Tj
1.6441 0 Td
(were)Tj
2.1259 0 Td
(resistant)Tj
3.583 0 Td
(to)Tj
1.0261 0 Td
(ciprofloxacin.)Tj
5.709 0 Td
(Miranda)Tj
/F10 1 Tf
3.6963 0 Td
[()8()]TJ
0.9128 0 Td
[()11()]TJ
/F7 1 Tf
(.)Tj
1.1622 0 Td
(\(2014\))Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(])Tj
1.8481 0 Td
(studied)Tj
3.1578 0 Td
(the)Tj
1.4684 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
1.0148 0 Td
(anti-)Tj
-35.1947 -1.2983 Td
(biotic)Tj
2.4888 0 Td
(resistance)Tj
4.1328 0 Td
(to)Tj
1.0262 0 Td
(urinary)Tj
3.1918 0 Td
(tract)Tj
2.0466 0 Td
(infections)Tj
4.1499 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(city)Tj
1.6667 0 Td
(of)Tj
1.0148 0 Td
(S)Tj
/F11 1 Tf
[()]TJ
/F7 1 Tf
(o)Tj
1.6328 0 Td
(Paulo)Tj
2.4945 0 Td
(during)Tj
2.931 0 Td
(two)Tj
1.7064 0 Td
(periods:)Tj
3.4242 0 Td
(2005)Tj
-34.4123 -1.2983 Td
(2006)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(20102011.)Tj
4.7678 0 Td
(They)Tj
2.2394 0 Td
(found)Tj
2.6192 0 Td
(a)Tj
0.6519 0 Td
(significant)Tj
4.388 0 Td
(increase)Tj
3.4753 0 Td
(in)Tj
1.0318 0 Td
(bacterial)Tj
3.6283 0 Td
(resistance)Tj
4.1329 0 Td
(to)Tj
1.0205 0 Td
(most)Tj
2.211 0 Td
(antibiot-)Tj
-34.0155 -1.3039 Td
(ics)Tj
1.2699 0 Td
(between)Tj
3.5262 0 Td
(these)Tj
2.2564 0 Td
(two)Tj
1.7121 0 Td
(periods,)Tj
3.4186 0 Td
(particularly)Tj
4.8132 0 Td
(to)Tj
1.0204 0 Td
(fluoroquinolones)Tj
7.115 0 Td
(\(90.1%)Tj
2.965 0 Td
(of)Tj
1.0148 0 Td
(infections)Tj
4.1555 0 Td
(were)Tj
2.1203 0 Td
(sus-)Tj
-35.3874 -1.2982 Td
(ceptible)Tj
3.3278 0 Td
(to)Tj
1.0205 0 Td
(ciprofloxacin)Tj
5.4878 0 Td
(in)Tj
1.0375 0 Td
(20052006)Tj
4.5411 0 Td
(vs)Tj
1.0374 0 Td
(83.4%)Tj
2.6249 0 Td
(in)Tj
1.0375 0 Td
(20102011\).)Tj
5.108 0 Td
(Global)Tj
2.8743 0 Td
(susceptibility)Tj
5.4425 0 Td
(of)Tj
/F10 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F10 1 Tf
0.9921 0 Td
[()7()10()12()]TJ
/F7 1 Tf
(,)Tj
-35.5462 -1.2983 Td
(the)Tj
1.4626 0 Td
(most)Tj
2.1997 0 Td
(common)Tj
3.8437 0 Td
(urinary)Tj
3.1862 0 Td
(tract)Tj
2.0409 0 Td
(infection)Tj
3.7871 0 Td
(agent,)Tj
2.6135 0 Td
(decreased)Tj
4.1272 0 Td
(from)Tj
2.1997 0 Td
(88.3%)Tj
2.6248 0 Td
(to)Tj
1.0205 0 Td
(86.1%,)Tj
2.8516 0 Td
(and)Tj
1.7235 0 Td
(resistance)Tj
-33.681 -1.3039 Td
(was)Tj
1.6951 0 Td
(greater)Tj
3.0103 0 Td
(among)Tj
2.9934 0 Td
(men)Tj
2.0126 0 Td
(and)Tj
1.7291 0 Td
(patients)Tj
3.3675 0 Td
(older)Tj
2.2961 0 Td
(than)Tj
2.0296 0 Td
(65)Tj
1.1735 0 Td
(years.)Tj
-19.111 -1.2983 Td
(The)Tj
1.7858 0 Td
(present)Tj
3.1634 0 Td
(study)Tj
2.3868 0 Td
(is,)Tj
1.0771 0 Td
(to)Tj
1.0262 0 Td
(our)Tj
1.6214 0 Td
(knowledge,)Tj
4.7678 0 Td
(the)Tj
1.474 0 Td
(first)Tj
1.8029 0 Td
(to)Tj
1.0261 0 Td
(focus)Tj
2.3244 0 Td
(on)Tj
1.2756 0 Td
(SED)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(antibiotic)Tj
4.0422 0 Td
(consumption)Tj
-31.9859 -1.2983 Td
(specifically)Tj
4.5694 0 Td
(in)Tj
1.0374 0 Td
(SSP)Tj
1.7292 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(analyse)Tj
3.1238 0 Td
(the)Tj
1.4683 0 Td
(micro-level)Tj
4.7509 0 Td
(variations)Tj
4.1669 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0147 0 Td
(Brazil's)Tj
3.1068 0 Td
(policy)Tj
2.6362 0 Td
(of)Tj
-35.2287 -1.2982 Td
(OTC)Tj
2.2393 0 Td
(sales)Tj
2.0466 0 Td
(abolishment.)Tj
5.3858 0 Td
(We)Tj
1.6101 0 Td
(have)Tj
2.0579 0 Td
(three)Tj
2.262 0 Td
(objectives:)Tj
-15.6017 -1.9049 Td
(1.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(estimate)Tj
3.5433 0 Td
(the)Tj
1.4683 0 Td
(impact)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(OTC)Tj
2.2393 0 Td
(sales)Tj
2.0466 0 Td
(prohibition)Tj
4.8075 0 Td
(on)Tj
1.2756 0 Td
(pharmacy)Tj
4.2009 0 Td
(antibiotic)Tj
4.0366 0 Td
(consumption)Tj
-30.4213 -1.2982 Td
(in)Tj
1.0318 0 Td
(SSP.)Tj
-2.2336 -1.8992 Td
(2.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(identify)Tj
3.2938 0 Td
(regions)Tj
3.1635 0 Td
(with)Tj
1.9955 0 Td
(higher)Tj
2.8063 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(pharmacy)Tj
4.201 0 Td
(antibiotic)Tj
4.0365 0 Td
(consumption,)Tj
5.7713 0 Td
(both)Tj
2.0579 0 Td
(before)Tj
2.7439 0 Td
(and)Tj
-34.7979 -1.2983 Td
(after)Tj
2.0353 0 Td
(implementation)Tj
6.6387 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(policy.)Tj
-12.3589 -1.9049 Td
(3.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(identify)Tj
3.2938 0 Td
(determinants)Tj
5.5389 0 Td
(of)Tj
1.0148 0 Td
(higher)Tj
2.8063 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(pharmacy)Tj
4.2009 0 Td
(antibiotic)Tj
4.0365 0 Td
(consumption)Tj
5.5445 0 Td
(and)Tj
1.7348 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-33.9135 -1.2982 Td
(policy)Tj
2.6362 0 Td
(effect.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 228.9826 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 211.9748 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Data)Tj
2.1203 0 Td
(on)Tj
1.2755 0 Td
(antimicrobial)Tj
5.6126 0 Td
(annual)Tj
2.9593 0 Td
(wholesale)Tj
4.0706 0 Td
(sales)Tj
2.0466 0 Td
(across)Tj
2.6759 0 Td
(SSP)Tj
1.7348 0 Td
(were)Tj
2.1203 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1848 0 Td
(Intercontinental)Tj
-29.6161 -1.2982 Td
(Medical)Tj
3.4355 0 Td
(Statistics)Tj
3.702 0 Td
(Health)Tj
2.9197 0 Td
(Brazil,)Tj
2.7553 0 Td
(a)Tj
0.6519 0 Td
(healthcare)Tj
4.3313 0 Td
(consultancy)Tj
4.9947 0 Td
(organisation)Tj
5.227 0 Td
(for)Tj
1.389 0 Td
(pharmaceutical)Tj
-29.4064 -1.2983 Td
(industry)Tj
3.5773 0 Td
(research.)Tj
3.7813 0 Td
(It)Tj
0.8561 0 Td
(consisted)Tj
3.9401 0 Td
(of)Tj
1.0148 0 Td
(sales)Tj
2.041 0 Td
(to)Tj
1.0261 0 Td
(establishments)Tj
6.1001 0 Td
(such)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(pharmacies,)Tj
5.0229 0 Td
(clinics)Tj
2.7609 0 Td
(and)Tj
1.7292 0 Td
(hospi-)Tj
-34.9226 -1.2982 Td
(tals;)Tj
1.7858 0 Td
(having)Tj
2.914 0 Td
(occurred)Tj
3.7984 0 Td
(from)Tj
2.2053 0 Td
(2008)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(2012.)Tj
2.3471 0 Td
(Data)Tj
2.126 0 Td
(were)Tj
2.1203 0 Td
(given)Tj
2.3811 0 Td
(by)Tj
1.1792 0 Td
(defined)Tj
3.2258 0 Td
(daily)Tj
2.1486 0 Td
(dose)Tj
2.041 0 Td
(\(DDD\),)Tj
3.3335 0 Td
(by)Tj
-34.7525 -1.304 Td
(municipality)Tj
5.2894 0 Td
(and)Tj
1.7291 0 Td
(by)Tj
1.1849 0 Td
(year.)Tj
2.1259 0 Td
(Data)Tj
2.1203 0 Td
(on)Tj
1.2756 0 Td
(total)Tj
2.0069 0 Td
(antibiotic)Tj
4.0365 0 Td
(consumption)Tj
5.5446 0 Td
(in)Tj
1.0375 0 Td
(SSP)Tj
1.7291 0 Td
(\(not)Tj
1.9162 0 Td
(divided)Tj
3.2144 0 Td
(by)Tj
1.1793 0 Td
(munici-)Tj
-34.3897 -1.2982 Td
(pality\))Tj
2.7779 0 Td
(were)Tj
2.1203 0 Td
(also)Tj
1.7688 0 Td
(available)Tj
3.668 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6519 0 Td
(monthly)Tj
3.6227 0 Td
(basis.)Tj
2.3754 0 Td
(DDD)Tj
2.4265 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(suggested)Tj
4.0762 0 Td
(unit)Tj
1.8595 0 Td
(for)Tj
1.389 0 Td
(measurement)Tj
5.6692 0 Td
(of)Tj
-35.9997 -1.2983 Td
(drug)Tj
2.1089 0 Td
(consumption)Tj
5.5502 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6577 0 Td
(population,)Tj
4.8132 0 Td
(being)Tj
2.4321 0 Td
(defined)Tj
3.2258 0 Td
(as:)Tj
/F10 1 Tf
-18.6235 -2.5001 Td
[( )-15(\n)1()6()]TJ
2.0919 0 Td
[()10()10(\r)12()6()7()]TJ
3.5603 0 Td
[()22()3()2()20()15()2()]TJ
3.1861 0 Td
[()6()16()12()22()11()2()6()16()6()7()]TJ
5.2724 0 Td
[()4()7()-3()]TJ
1.9049 0 Td
[()4()2()]TJ
1.4513 0 Td
[()4()22()]TJ
1.6328 0 Td
[()9()11()]TJ
1.3153 0 Td
[()]TJ
0.7029 0 Td
[()12()-9(\r)10()]TJ
2.0183 0 Td
[(\r)-4()-3()7()]TJ
1.9672 0 Td
[()9()11()]TJ
1.3153 0 Td
[()14()]TJ
1.1168 0 Td
[()6()16()12()]TJ
2.2791 0 Td
[()12()6()12()4()7()22()7()4()11()]TJ
4.1896 0 Td
[()12()]TJ
-34.0042 -1.3039 Td
[()6()12(\r)4()14()47()]TJ
/F7 1 Tf
1.2018 -1.2983 Td
(\(WHO)Tj
3.0388 0 Td
(Collaborating)Tj
5.7146 0 Td
(Centre)Tj
2.948 0 Td
(for)Tj
1.389 0 Td
(Drug)Tj
2.3187 0 Td
(Statistics)Tj
3.7077 0 Td
(Methodology,)Tj
5.7996 0 Td
(2014\))Tj
2.4661 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Antibiotic)Tj
4.2023 0 Td
(Consum)Tj
3.6639 0 Td
(ption)Tj
2.3456 0 Td
(Determinan)Tj
5.0812 0 Td
(ts)Tj
0.985 0 Td
(in)Tj
0.978 0 Td
(S)Tj
/F5 1 Tf
[( m)]TJ
/F0 1 Tf
(o)Tj
1.9701 0 Td
(Paulo)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0167)Tj
3.5434 0 Td
(885)Tj
2.6362 0 Td
(December)Tj
4.7622 0 Td
(12,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
BT
66.402 0 Td
(14)Tj
ET
Q
endstream
endobj
74 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 77 0 R/Contents 78 0 R/TrimBox[0 0 612 792]>>
endobj
75 0 obj
<>
endobj
79 0 obj
<>
endobj
80 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Roman def
/FontType 1 def
/FontBBox {-31 -250 1000 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Roman) readonly def
/BaseFontName (TeX_CM_Roman) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}S/8W}efFz~"7Mԗ3T3#mAE=90}c:o|y$)|DKf{(!✱դs'Xt{r6\C~-x{jFҘ{@]##')\}7l"ۂ8c.)a0KcyZ$FX(uØ!{uh\[l^d*BֿAJyPOM lJvNab?$h:`/A[ 88hxtXX*UT<NoR^@z
!cef WE(3ZmC:A~Y&w$ř/LGjq6Sπ4E0rrdyrx˫3JLqT|heT[?bqv\6Kw0ֻ#[[#Fo碜m w#ojsnlϴ=9 Żԕ)~\]G˧Ž9#iiՋToI.9[ڔl6l_vtK"JfKPč+:
Α/ (kw}
>qoF6EQO8Ql68ůĊɻ֕GNKEvw*70Uz7+*t8w͌`уg;5unV#/-VPoWHY+H%5̶bGPgsPU
v
"h$9;Ap52@\_A-0@i:0&"MW\45@27wRItgtEa5 ew#oH}TȒ)HEY$@W`rTmŽ^xlIC' U:* 3?RCG
hk~sA9+cUɅ;eoYyv@54oR
UeYPΚmu[*՛4z3vIk9UBřR29kӧf4ی4o0H?ǚ<._VhZu*`h>S
ao҄Ã(Kh',9s&/b$fGX==s2:=x?B<Ӂ:ͪbJ*EgDEg|s8, 1 4f&raBڶ]٠}$*U"*/y"7.VgS+'Q6h"3$\އ7U9چۯj1}21WH;=|{pb=x@OѢ^[ngoDU'suIҢ!+VCAb2BsSm
x\=Q,pt響m!.;jX2_f;_$䦐>{ןŌR"=@M
k9٦LnQkջy{yg+_CJ;DU.2qKf ]cj[6$i/@f ^$JnY:4*itKD"_U5Zay";4\.a`a=Bhlru M:%_8Rx=mo9ިӍj&q&dWf?K
$r\;7oU'c{apDT=Zţ!.% c/=3tg|}AGd`#oe )hZ#Č4vQnTERz*uhc}(<T~?ԀlifF!W_Qo0>Tc?gߝv|K{&h{Qza
x
2)3jd@"wSt@![*SZ4\z;,ܵ
❦u@HpΒRMroҜq{z
(`wN
PcT(Sݣ\.]ƿ}/xb)7!P3hQRwYBІd|ՔF ֺw"m%r8= (Ah&x|Fz&E{fup&rxyzNt[AqR9M9N#C1cc9w\GCUN!RaoB$e W-U7ޓweaBoֳD(c6֧droG2tʈmV):ƣDa)r8>HrVm" cu40q?$-@;o,ZUHL6$ {%c#lV_.MBa6[+U3D?rfgv,m,۠8?4}ݏşcVRy5NRP_\Wz囔Zf}&5}Hf
ڗrm@0|NL}B婭$=;Ӻ֚Dȷ;NXf9&SR85+&W]
(
ţ8q ZITrM|bd
s娶 u" ]'Q+>@2Yƭ_vh\goܡn<g$wn_` _u\J!!.5^ ϓ/q
-s#+GzKcggh҇*FAV4cOcBGcf)=Bh(CX\@"8O{J
vXgn8nڧML'D/)(tD~/wF+Ќ:/+=z
EE0\a47 =c]c9H5vEYu{[7_G7>;12ч%V3iw\i ejS}K 74E.bo(/@Q-}]8TIռqw=5ѤrXO96z 96$oXIHLg_FeBP$f`>(R6q]htif N}HjV*dMv^?;[:4HFAe@5$۬x"mS~_wOn['[]a5N1&/8yiw; Dm֣@2Ur>xHDAɵFO\[D(ki=|[2Bo)ʽɢ=ȐU;,Э(W]lC!\OV5, aeI+u