Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
O'Neill, Paul M; Amewu, Richard K; Nixon, Gemma L; Bousejra ElGarah, Fatima; Mungthin, Mathirut; Chadwick, James; Shone, Alison E; Vivas, Livia; Lander, Hollie; Barton, Victoria; +9 more...Muangnoicharoen, Sant; Bray, Patrick G; Davies, Jill; Park, B Kevin; Wittlin, Sergio; Brun, Reto; Preschel, Michael; Zhang, Kesheng; and Ward, Stephen A
(2010)
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
Angewandte Chemie (International ed in English), 49 (33).
pp. 5693-5697.
ISSN 1433-7851
DOI: 10.1002/anie.201001026
| Item Type | Article |
|---|---|
| Keywords | antimalarial agents, drug development, endoperoxides, medicinal, chemistry, tetraoxanes, MALARIA TREATMENT, RESISTANCE, STABILITY |
| ISI | 280891000015 |
| Date Deposited | 17 Oct 2011 14:10 |