Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

Paul M O'Neill ; Richard K Amewu ; Gemma L Nixon ; Fatima Bousejra ElGarah ; Mathirut Mungthin ; James Chadwick ; Alison E Shone ; Livia Vivas ; Hollie Lander ; Victoria Barton ; +9 more... Sant Muangnoicharoen ; Patrick G Bray ; Jill Davies ; B Kevin Park ; Sergio Wittlin ; Reto Brun ; Michael Preschel ; Kesheng Zhang ; Stephen A Ward ; (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie (International ed in English), 49 (33). pp. 5693-5697. ISSN 1433-7851 DOI: 10.1002/anie.201001026