Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Thye, T; Vannberg, FO; Wong, SH; Owusu-Dabo, E; Osei, I; Gyapong, J; Sirugo, G; Sisay-Joof, F; Enimil, A; Chinbuah, MA; +23 more...Floyd, S
; Warndorff, DK; Sichali, L; Malema, S; Crampin, AC; Ngwira, B; Teo, YY; Small, K; Rockett, K; Kwiatkowski, D; Fine, PE; Hill, PC; Newport, M; Lienhardt, C; Adegbola, RA; Corrah, T; Ziegler, A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, AP; Meyer, CG; Horstmann, RD; Hill, AV and
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
; Warndorff, DK; Sichali, L; Malema, S; Crampin, AC; Ngwira, B; Teo, YY; Small, K; Rockett, K; Kwiatkowski, D; Fine, PE; Hill, PC; Newport, M; Lienhardt, C; Adegbola, RA; Corrah, T; Ziegler, A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, AP; Meyer, CG; Horstmann, RD; Hill, AV and
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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