Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Thye, Thorsten; Vannberg, Fredrik O; Wong, Sunny H; Owusu-Dabo, Ellis; Osei, Ivy; Gyapong, John; Sirugo, Giorgio; Sisay-Joof, Fatou; Enimil, Anthony; Chinbuah, Margaret A; +23 more...Floyd, Sian
; Warndorff, David K; Sichali, Lifted; Malema, Simon; Crampin, Amelia C; Ngwira, Bagrey; Teo, Yik Y; Small, Kerrin; Rockett, Kirk; Kwiatkowski, Dominic; Fine, Paul E; Hill, Philip C; Newport, Melanie; Lienhardt, Christian; Adegbola, Richard A; Corrah, Tumani; Ziegler, Andreas; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, Andrew P; Meyer, Christian G; Horstmann, Rolf D; and Hill, Adrian VS
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
; Warndorff, David K; Sichali, Lifted; Malema, Simon; Crampin, Amelia C; Ngwira, Bagrey; Teo, Yik Y; Small, Kerrin; Rockett, Kirk; Kwiatkowski, Dominic; Fine, Paul E; Hill, Philip C; Newport, Melanie; Lienhardt, Christian; Adegbola, Richard A; Corrah, Tumani; Ziegler, Andreas; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, Andrew P; Meyer, Christian G; Horstmann, Rolf D; and Hill, Adrian VS
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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