Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Thorsten
Thye
;
Fredrik O
Vannberg
;
Sunny H
Wong
;
Ellis
Owusu-Dabo
;
Ivy
Osei
;
John
Gyapong
;
Giorgio
Sirugo
;
Fatou
Sisay-Joof
;
Anthony
Enimil
;
Margaret A
Chinbuah
;
+23 more...
Sian
Floyd
;
David K
Warndorff
;
Lifted
Sichali
;
Simon
Malema
;
Amelia C
Crampin
;
Bagrey
Ngwira
;
Yik Y
Teo
;
Kerrin
Small
;
Kirk
Rockett
;
Dominic
Kwiatkowski
;
Paul E
Fine
;
Philip C
Hill
;
Melanie
Newport
;
Christian
Lienhardt
;
Richard A
Adegbola
;
Tumani
Corrah
;
Andreas
Ziegler
;
African TB Genetics Consortium
;
Wellcome Trust Case Control Consortium
;
Andrew P
Morris
;
Christian G
Meyer
;
Rolf D
Horstmann
;
Adrian VS
Hill
;
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
;
David K
Warndorff
;
Lifted
Sichali
;
Simon
Malema
;
Amelia C
Crampin
;
Bagrey
Ngwira
;
Yik Y
Teo
;
Kerrin
Small
;
Kirk
Rockett
;
Dominic
Kwiatkowski
;
Paul E
Fine
;
Philip C
Hill
;
Melanie
Newport
;
Christian
Lienhardt
;
Richard A
Adegbola
;
Tumani
Corrah
;
Andreas
Ziegler
;
African TB Genetics Consortium
;
Wellcome Trust Case Control Consortium
;
Andrew P
Morris
;
Christian G
Meyer
;
Rolf D
Horstmann
;
Adrian VS
Hill
;
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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picture_as_pdf - Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.pdf
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