This is the protocol for a review and there is no abstract. The objectives are as follows: This review seeks to examine the effectiveness of prevention interventions for MSM that combine at least two of the three categories of intervention modality (biomedical, behavioural and structural) compared either to other HIV prevention interventions or to minimal/no HIV prevention. Below, descriptions of the criteria that will be used to categorise intervention components are provided under the heading Types of interventions' and the full list of outcomes of interest are provided in the section Types of outcome measures'. All planned comparisons are detailed in the section Data synthesis', followed by the planned variables of interest for subgroup and meta-regression analyses.