A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Crowe, Francesca L;
Key, Timothy J;
Allen, Naomi E;
Appleby, Paul N;
Overvad, Kim;
Grønbæk, Henning;
Tjønneland, Anne;
Halkjær, Jytte;
Dossus, Laure;
Boeing, Heiner;
+30 more...Kröger, Janine;
Trichopoulou, Antonia;
Zylis, Dimosthenis;
Trichopoulos, Dimitrios;
Boutron-Ruault, Marie-Christine;
de Lauzon-Guillain, Blandine;
Clavel-Chapelon, Françoise;
Palli, Domenico;
Berrino, Franco;
Panico, Salvatore;
Tumino, Rosario;
Sacerdote, Carlotta;
Bueno-de-Mesquita, H Bas;
van Gils, Carla H;
Peeters, Petra HM;
Gram, Inger T;
Rodríguez, Laudina;
Jakszyn, Paula;
Molina-Montes, Esther;
Navarro, Carmen;
Barricarte, Aurelio;
Larrañaga, Nerea;
Khaw, Kay-Tee;
Rodwell, Sheila;
Rinaldi, Sabina;
Slimani, Nadia;
Norat, Teresa;
Gallo, Valentina;
Riboli, Elio;
Kaaks, Rudolf;
(2011)
A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Annals of human biology, 38 (2).
pp. 194-202.
ISSN 0301-4460
DOI: https://doi.org/10.3109/03014460.2010.507221
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BACKGROUND: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. AIM: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. SUBJECTS AND METHODS: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). RESULTS: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). CONCLUSION: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
