Mackenzie, Grant A; Plumb, Ian D; Sambou, Sana; Saha, Debasish; Uchendu, Uchendu; Akinsola, Bolanle; Ikumapayi, Usman N; Baldeh, Ignatius; Usuf, Effua; Touray, Kebba; +9 more... Jasseh, Momodou; Howie, Stephen RC; Wattiaux, Andre; Lee, Ellen; Knoll, Maria Deloria; Levine, Orin S; Greenwood, Brian M; Adegbola, Richard A; Hill, Philip C; (2012) Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. PLoS medicine, 9 (1). e1001161-. ISSN 1549-1277 DOI: https://doi.org/10.1371/journal.pmed.1001161
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Abstract
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings.
Item Type | Article |
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Faculty and Department |
Faculty of Infectious and Tropical Diseases > Dept of Disease Control Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) MRC Gambia > GM-Disease Control and Elimination Theme MRC Gambia > GM-Gambia Clinical Services/Comms |
Research Centre | Vaccine Centre |
PubMed ID | 22272192 |
ISI | 300419600009 |
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