Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.
Mackenzie, Grant A;
Plumb, Ian D;
Sambou, Sana;
Saha, Debasish;
Uchendu, Uchendu;
Akinsola, Bolanle;
Ikumapayi, Usman N;
Baldeh, Ignatius;
Usuf, Effua;
Touray, Kebba;
+9 more...Jasseh, Momodou;
Howie, Stephen RC;
Wattiaux, Andre;
Lee, Ellen;
Knoll, Maria Deloria;
Levine, Orin S;
Greenwood, Brian M;
Adegbola, Richard A;
Hill, Philip C;
(2012)
Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.
PLoS medicine, 9 (1).
e1001161-.
ISSN 1549-1277
DOI: https://doi.org/10.1371/journal.pmed.1001161
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Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings.
