Pocock, Stuart J; Clayton, Tim C; Stone, Gregg W; (2015) Challenging Issues in Clinical Trial Design: Part 4 of a 4-Part Series on Statistics for Clinical Trials. Journal of the American College of Cardiology, 66 (25). pp. 2886-2898. ISSN 0735-1097 DOI: https://doi.org/10.1016/j.jacc.2015.10.051
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Abstract
As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring Committees (including when to stop a trial early), and the role of adaptive designs. All topics are illustrated by relevant examples from cardiology trials.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Medical Statistics |
Research Centre | ?? 208138 ?? |
PubMed ID | 26718676 |
ISI | 366945900012 |
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