Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Yufei
Wang
;
Peter
Broderick
;
Emily
Webb
;
Xifeng
Wu
;
Jayaram
Vijayakrishnan
;
Athena
Matakidou
;
Mobshra
Qureshi
;
Qiong
Dong
;
Xiangjun
Gu
;
Wei Vivien
Chen
;
+4 more...
Margaret R
Spitz
;
Timothy
Eisen
;
Christopher I
Amos
;
Richard S
Houlston
;
(2008)
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Nature genetics, 40 (12).
pp. 1407-1409.
ISSN 1061-4036
DOI: 10.1038/ng.273
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
Item Type | Article |
---|---|
ISI | 261215900015 |
Date Deposited | 17 Oct 2011 13:55 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695928 (OA Location)
- 10.1038/ng.273 (DOI)
- 18978787 (PubMed)
ORCID: https://orcid.org/0000-0002-4019-7456