CASP8 D302H and meningioma risk: an analysis of five case-control series.

Lara Bethke ; Kate Sullivan ; Emily Webb ORCID logo ; Anne Murray ; Minouk Schoemaker ; Anssi Auvinen ; Anne Kiuru ; Tiina Salminen ; Christoffer Johansen ; Helle Collatz Christensen ; +12 more... Kenneth Muir ; Patricia McKinney ; Sarah Hepworth ; Polyxeni Dimitropoulou ; Artitaya Lophatananon ; Maria Feychting ; Stefan Lönn ; Anders Ahlbom ; Beatrice Malmer ; Roger Henriksson ; Anthony Swerdlow ; Richard Houlston ; (2009) CASP8 D302H and meningioma risk: an analysis of five case-control series. Cancer letters, 273 (2). pp. 312-315. ISSN 0304-3835 DOI: 10.1016/j.canlet.2008.08.010
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Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.
Item Type Article
ISI 262582100017
Date Deposited 17 Oct 2011 13:54

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