The common D302H variant of CASP8 is associated with risk of glioma.
Bethke, Lara; Sullivan, Kate; Webb, Emily
; Murray, Anne; Schoemaker, Minouk; Auvinen, Anssi; Kiuru, Anne; Salminen, Tiina; Johansen, Christoffer; Christensen, Helle Collatz; +12 more...Muir, Kenneth; McKinney, Patricia; Hepworth, Sarah; Dimitropoulou, Polyxeni; Lophatananon, Artitaya; Feychting, Maria; Lönn, Stefan; Ahlbom, Anders; Malmer, Beatrice; Henriksson, Roger; Swerdlow, Anthony; and Houlston, Richard
(2008)
The common D302H variant of CASP8 is associated with risk of glioma.
Cancer epidemiology, biomarkers & prevention, 17 (4).
pp. 987-989.
ISSN 1055-9965
DOI: 10.1158/1055-9965.EPI-07-2807
Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.
Item Type | Article |
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ISI | 254969000035 |
Date Deposited | 17 Oct 2011 13:54 |
ORCID: https://orcid.org/0000-0002-4019-7456