Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.

Bousema, J Teun; Roeffen, Will; van der Kolk, Mike; de Vlas, Sake J; van de Vegte-Bolmer, Marga; Bangs, Michael J; Teelen, Karina; Kurniawan, Liliana; Maguire, Jason D; Baird, J Kevin; +1 more... Sauerwein, Robert W; (2006) Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia. The American journal of tropical medicine and hygiene, 74 (3). pp. 425-431. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.2006.74.425

Abstract

Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51-9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36-10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology > Dept of Immunology and Infection (-2019)
Research Centre	Malaria Centre
PubMed ID	16525101
ISI	235923300013