The article discusses the smallpox inoculation in the Ottoman empire. It states that women from the Caucasus who served in the harem of the Turkish Sultan were inoculated in their childhood, and has brought the variolation to the court of the Ottoman Porte. It also says that the Seljuk Turks have introduced the method of variolation in the Asia Minor. It adds that Ottoman doctors have introduced the methods of cutaneous inoculation in Europe in the eighteenth century.