Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

Kirwan, DE; Ugarte-Gil, C; Gilman, RH; Caviedes, L; Rizvi, H; Ticona, E; Chavez, G; Cabrera, JL; Matos, ED; Evans, CA; +3 more...Moore, DA

; Friedland, JS; Lymph Node TB Working Group, Peru and (2015) Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. Journal of clinical microbiology, 54 (1). pp. 185-189. ISSN 0095-1137 DOI: 10.1128/JCM.02227-15

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In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.