Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

Daniela E Kirwan ; Cesar Ugarte-Gil ; Robert H Gilman ; Luz Caviedes ; Hasan Rizvi ; Eduardo Ticona ; Gonzalo Chavez ; José Luis Cabrera ; Eduardo D Matos ; Carlton A Evans ; +3 more... David AJ Moore

; Jon S Friedland ; Lymph Node TB Working Group, Peru ; (2015) Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. Journal of clinical microbiology, 54 (1). pp. 185-189. ISSN 0095-1137 DOI: 10.1128/JCM.02227-15

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In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.