© 2015 World Heart Federation (Geneva). The vision of the World Heart Federation is to drive efforts to reduce premature cardiovascular disease-related death globally by at least 25% by 2025. To help achieve this goal, the World Heart Federation has initiated theEmerging Leaders program, which aims to use expertise among leaders in implementation science, health systems, and health policy research and to work with at least 100 emerging leaders over the next decade to initiate and facilitate cardiovascular disease prevention activities globally and in every region of the world. In this report, we describe the rationale for and characteristics of the Emerging Leaders program, including its training objectives, methods, and future directions. The Emerging Leaders program represents a major opportunity for the World Heart Federation, its member organizations, and the emerging leaders themselves to leverage their collective strengths toward achieving the ambitious, yet achievable, "25× 25" goal through an innovative global collaborative leadership-enhancing experience.