Bioactive metabolites from the South African marine mollusk Trimusculus costatus.
van Wyk, Albert WW;
Gray, Christopher A;
Whibley, Catherine E;
Osoniyi, Omolaja;
Hendricks, Denver T;
Caira, Mino R;
Davies-Coleman, Michael T;
(2008)
Bioactive metabolites from the South African marine mollusk Trimusculus costatus.
Journal of natural products, 71 (3).
pp. 420-425.
ISSN 0163-3864
DOI: https://doi.org/10.1021/np070612y
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A reinvestigation of extracts of the endemic South African intertidal limpet Trimusculus costatus yielded the known labdane diterpenes 6beta,7alpha-diacetoxylabda-8,13 E-dien-15-ol ( 1) and 2alpha,6beta,7alpha-triacetoxylabda-8,13 E-dien-15-ol ( 2) and three new metabolites, 6beta,7alpha,15-triacetoxylabda-8,13 E-diene ( 3), 3alpha,11-dihydroxy-9,11-seco-cholest-4,7-dien-6,9-dione ( 4), and cholest-7-en-3,5,7-triol ( 5). Chiral derivatization and X-ray analysis were used to confirm the labdane absolute configuration of 2. Compounds 1, 2 and 4 exhibited moderate activity (3-25 microM) against the WHCO1 human esophageal cancer cell line.
