Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Alice C
Eziefula
;
Helmi
Pett
;
Lynn
Grignard
;
Salome
Opus
;
Moses
Kiggundu
;
Moses R
Kamya
;
Shunmay
Yeung
;
Sarah G
Staedke
;
Teun
Bousema
;
Chris
Drakeley
;
(2014)
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Antimicrobial agents and chemotherapy, 58 (8).
pp. 4971-4973.
ISSN 0066-4804
DOI: 10.1128/AAC.02889-14
;
Salome
Opus
;
Moses
Kiggundu
;
Moses R
Kamya
;
Shunmay
Yeung
;
Sarah G
Staedke
;
Teun
Bousema
;
Chris
Drakeley
;
(2014)
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Antimicrobial agents and chemotherapy, 58 (8).
pp. 4971-4973.
ISSN 0066-4804
DOI: 10.1128/AAC.02889-14
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
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