Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Eziefula, AC; Pett, H; Grignard, L
; Opus, S; Kiggundu, M; Kamya, MR; Yeung, S; Staedke, SG; Bousema, T; Drakeley, C and
(2014)
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Antimicrobial agents and chemotherapy, 58 (8).
pp. 4971-4973.
ISSN 0066-4804
DOI: 10.1128/AAC.02889-14
; Opus, S; Kiggundu, M; Kamya, MR; Yeung, S; Staedke, SG; Bousema, T; Drakeley, C and
(2014)
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Antimicrobial agents and chemotherapy, 58 (8).
pp. 4971-4973.
ISSN 0066-4804
DOI: 10.1128/AAC.02889-14
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
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