In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.
Baraka, V; Tinto, H; Valea, I; Fitzhenry, R; Delgado-Ratto, C; Mbonye, MK; Van Overmeir, C; Rosanas-Urgell, A; Van Geertruyden, J; D'Alessandro, U
; +1 more...Erhart, A and
(2014)
In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.
Antimicrobial agents and chemotherapy, 59 (1).
pp. 734-737.
ISSN 0066-4804
DOI: 10.1128/AAC.03647-14
; +1 more...Erhart, A and
(2014)
In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.
Antimicrobial agents and chemotherapy, 59 (1).
pp. 734-737.
ISSN 0066-4804
DOI: 10.1128/AAC.03647-14
Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.
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