Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

Nyberg, ST; Fransson, EI; Heikkilä, K; Alfredsson, L; Casini, A; Clays, E; De Bacquer, D; Dragano, N; Erbel, R; Ferrie, JE; +19 more...Hamer, M; Jöckel, K; Kittel, F; Knutsson, A; Ladwig, K; Lunau, T; Marmot, MG; Nordin, M; Rugulies, R; Siegrist, J; Steptoe, A; Westerholm, PJ; Westerlund, H; Theorell, T; Brunner, EJ; Singh-Manoux, A; Batty, GD; Kivimäki, M; IPD-Work Consortium and (2013) Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. PloS one, 8 (6). e67323-. ISSN 1932-6203 DOI: 10.1371/journal.pone.0067323
Copy

BACKGROUND: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association. METHODOLOGY AND PRINCIPAL FINDINGS: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain. CONCLUSIONS: In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.


picture_as_pdf
pone.0067323.pdf
subject
Published Version
Available under Creative Commons: Attribution 3.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads