Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi.

Bansode, Vijay; Drebert, Zuzanna J; Travers, Simon AA; Banda, Emmanuel; Molesworth, Anna; Crampin, Amelia; Ngwira, Bagrey; French, Neil; Glynn, Judith R; McCormack, Grace P; (2010) Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. AIDS research and human retroviruses, 27 (4). pp. 439-444. ISSN 0889-2229 DOI: https://doi.org/10.1089/aid.2010.0203

Abstract

In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre	Antimicrobial Resistance Centre (AMR)
PubMed ID	20950147
ISI	289074400014
Related URLs	OA Location