Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.
Gadalla, Nahla B; Adam, Ishag; Elzaki, Salah-Eldin; Bashir, Sahar; Mukhtar, Izdihar; Oguike, Mary; Gadalla, Amal; Mansour, Fathi; Warhurst, David; El-Sayed, Badria B; and +1 more...Sutherland, Colin J
(2011)
Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.
Antimicrobial agents and chemotherapy, 55 (11).
pp. 5408-5411.
ISSN 0066-4804
DOI: 10.1128/AAC.05102-11
(2011)
Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.
Antimicrobial agents and chemotherapy, 55 (11).
pp. 5408-5411.
ISSN 0066-4804
DOI: 10.1128/AAC.05102-11
Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.
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