Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda.
Kaleebu, Pontiano;
French, Neil;
Mahe, Cedric;
Yirrell, David;
Watera, Christine;
Lyagoba, Fred;
Nakiyingi, Jessica;
Rutebemberwa, Alleluiah;
Morgan, Dilys;
Weber, Jonathan;
+2 more...Gilks, Charles;
Whitworth, Jimmy;
(2002)
Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda.
The Journal of infectious diseases, 185 (9).
pp. 1244-1250.
ISSN 0022-1899
DOI: https://doi.org/10.1086/340130
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The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07-1.56; P=.009) and with a lower CD4 cell count during follow-up (P=.001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A.
