Dourado, I; Rios, MH; Pereira, SMM; Cunha, SS; Ichihara, MY; Goes, JCL; Rodrigues, LC; Bierrenbach, AL; Barreto, ML; (2003) Rates of adverse reactions to first and second doses of BCG vaccination: results of a large community trial in Brazilian schoolchildren. The international journal of tuberculosis and lung disease, 7 (4). pp. 399-402. ISSN 1027-3719 https://researchonline.lshtm.ac.uk/id/eprint/16536
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https://researchonline.lshtm.ac.uk/id/eprint/16536
Abstract
OBJECTIVE: To evaluate the incidence of adverse reactions to first and second bacille Calmette-Guérin (BCG) vaccination in schoolchildren. SETTING AND DESIGN: Enhanced surveillance in a Brazilian trial. Suspected reactions were reported to a nurse who visited cases and completed a standard form. RESULTS: Among 71341 schoolchildren studied, 33 reactions were reported. Of these, 25 fulfilled the criteria, resulting in a rate of one per 2854 vaccinations, with no deaths or BCG-osis. Reactions to second doses were more common than to first BCG vaccinations, but this difference was not statistically significant. CONCLUSIONS: Adverse reactions to a second dose of BCG may be more frequent than reactions to a first dose, but they are still rare events.
| Item Type | Article |
|---|---|
| Keywords | BCG vaccine, adverse reactions, BCG-REVAC, Tuberculosis |
| Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
| Research Centre | Vaccine Centre |
| PubMed ID | 12729348 |
| ISI | 182127700017 |
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