Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: a cohort study.
Hoffmann, Christopher J;
Charalambous, Salome;
Grant, Alison D;
Morris, Lynn;
Churchyard, Gavin J;
Chaisson, Richard E;
(2014)
Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: a cohort study.
Tropical medicine & international health, 19 (2).
pp. 236-239.
ISSN 1360-2276
DOI: https://doi.org/10.1111/tmi.12237
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.