The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda.
Morgan, D;
Kaleebu, P;
Whitworth, J;
Yirrell, D;
Rutebemberwa, A;
Shier, R;
Sebabi, B;
Gilmour, J;
Eotu, H;
Omoding, N;
+1 more...Gotch, F;
(2001)
The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda.
International journal of STD & AIDS, 12 (2).
pp. 116-121.
ISSN 0956-4624
DOI: https://doi.org/10.1258/0956462011916758
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We compared HIV-1 RNA levels using the nucleic acid sequenced based amplification (NASBA) test kit in 2 samples taken one year apart from participants infected with env subtype A or D in a population-based cohort in Uganda. Fifty participants were infected with subtype A and 70 with subtype D. HIV-1 RNA levels were significantly higher in subtype D unadjusted (P=0.001), and after adjusting for age, gender, and CD4 count (P<0.001). Eighty-six participants had HIV-1 RNA measurements in both years and 67 (78%) were within one log10 of their result a year before. There was no relationship between the difference in log viral load and proportion of CD4 change. Individuals infected with subtype D had a higher average increase in viral load and this was statistically significant if adjusted for baseline levels and CD4 count (P=0.015).
