Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.
Ariyoshi, Koya;
Berry, Neil;
Cham, Fatim;
Jaffar, Shabbar;
Schim van der Loeff, Maarten;
Jobe, Ousman;
N'Gom, Pa Tamba;
Larsen, Olav;
Andersson, Sören;
Aaby, Peter;
+1 more...Whittle, Hilton;
(2003)
Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.
The Journal of infectious diseases, 188 (11).
pp. 1648-1651.
ISSN 0022-1899
DOI: https://doi.org/10.1086/379780
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.
